1-Iodo-4-(4,4,4-trifluorobutoxy)benzene | 280776-49-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Iodo-4-(4,4,4-trifluorobutoxy)benzene
• CAS: 280776-49-0
• 化学式: C₁₀H₁₀F₃IO
• 分子量: 330.08
• InChiKey: BRPUJVSISRDJHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP3239134A1

  公开（公告）日：2017-11-01

  The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

  本发明涉及式 I 和 I'的吡啶酮酰胺化合物或其药学上可接受的盐类，可用作钠通道抑制剂： 本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗包括疼痛在内的各种疾病的方法。
• PROCESS FOR PREPARING PYRIDONE AMIDES WHICH ARE MODULATORS OF SODIUM CHANNELS AND INTERMEDIATE COMPOUNDS USED THEREIN
  申请人：Vertex Pharmaceuticals Incorporated

  公开号：EP3865475A1

  公开（公告）日：2021-08-18

  The invention relates to pyridone amide compounds of formula I and I'or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain.

  本发明涉及式 I 和 I'的吡啶酮酰胺化合物或其药学上可接受的盐类，可用作钠通道抑制剂： 本发明还提供了包含本发明化合物的药学上可接受的组合物，以及使用该组合物治疗包括疼痛在内的各种疾病的方法。
• LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS
  申请人：QinetiQ Limited

  公开号：EP1150937A1

  公开（公告）日：2001-11-07
• ARYL DIHYDROPYRIDINONES AND PIPERIDINONES AS MGAT2 INHIBITORS
  申请人：Bristol-Myers Squibb Company

  公开号：EP2785693B1

  公开（公告）日：2016-05-18
• [EN] LIQUID CRYSTALLINE TRIFLUORO-SUBSTITUTED COMPOUNDS<br/>[FR] COMPOSES CRISTALLINS LIQUIDES A DI-SUBSTITUTION TRIFLUORO
  申请人：SECR DEFENCE

  公开号：WO2000039062A1

  公开（公告）日：2000-07-06

  Compounds are provided of the formula for use in a range of liquid crystal display devices (formula I) wherein n may be 0, 1 or 2, A1, A2, A3 are independently chosen from 1,4-disubstituted benzene, 2,5-disubstituted pyridine, 2,6-disubstituted naphthalene; laterally substituted 1,4-disubstituted benzene, laterally substituted 2,5-disubstituted pyrimidine, laterally substituted 2,5-disubstituted pyridine, laterally substituted 2,5-disubstituted naphthalene wherein the lateral substituents are independently selected from F, CI, Br or CN and may be present in any of the available substitution positions; 1,4-disubstituted bicyclo(2.2.2)octane, trans-1,4-disubstituted cyclohexane, trans-2,5-disubstituted dioxane, 1,4-disubstituted piperidine, Z1, Z2 are independently chosen from a direct bond, COO, OOC, C2H4, CH2O, OCH2, C4H8, C3H6O, (E)-CH=CHC2H4, (Z)-CH2CH=CHCH2, (E)-CH=CHCH2O, -C≡C-, Z3 may be C4H8, OC3H6, (E)-CH=CHC2H4, (Z)-CH2CH=CHCH2, (E)-OCH2CH=CH, -C≡C-, C2H4; R may be alkyl, alkoxy, alkenyl, alkenyloxy, alkanoyloxy, alkenoyloxy or OCmF2m+1, R may contain 1 to 20 carbon atoms and may be branched or a straight chain m is 1-20.