1,3-dipropyl-8-(4-carbobenzoxypiperidinyl)xanthine | 112683-80-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 1,3-dipropyl-8-(4-carbobenzoxypiperidinyl)xanthine
• 英文别名: benzyl 4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)piperidine-1-carboxylate
• CAS: 112683-80-4
• 化学式: C₂₄H₃₁N₅O₄
• 分子量: 453.541
• InChiKey: BDBQGKQNXVQYQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.22
• 重原子数：
  33.0
• 可旋转键数：
  7.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  102.22
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  1,3-dipropyl-8-(4-carbobenzoxypiperidinyl)xanthine 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 溶剂黄146 为溶剂， 反应 1.0h， 以36%的产率得到1,3-dipropyl-8-(4-piperidinyl)xanthine
  参考文献：
  名称：

  8-Aryl- and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors

  摘要：

  A series of 1,3-dipropylxanthines were prepared with a variety of substituents at the 8-position. These included 8-aryl and 8-cycloalkyl groups. Polar carboxylate and carboxamide moieties were introduced as aryl substituents to increase water solubility. 1,3-Dipropyl-8-[2-hydroxy-4-[(carboxymethyl)oxy]phenyl]xanthine provided a functionalized congener with high potency (Ki = 37 nM) and selectivity (54-fold) for A1-adenosine receptors. This congener was used for preparation of a series of other analogues, some with higher potency and some with higher selectivity. 8-Cyclopentyl- and 8-cyclohexyl-1,3-dipropylxanthines were both very potent (Ki = 1-1.5 nM) and selective for A1 receptors, while 8-cycloalkylmethyl analogues were 10-fold less potent, but still very selective for A1 receptors. 8-Piperidinyl and 8-pyrazinyl analogues had very low activities as adenosine receptor antagonists.

  DOI：

  10.1021/jm00398a020
• 作为产物：
  描述：

  氯甲酸苄酯 在 sodium hydroxide 、 sodium ethanolate 、 N,N'-二异丙基碳二亚胺 作用下， 以 甲醇 、 乙醇 为溶剂， 反应 5.0h， 生成 1,3-dipropyl-8-(4-carbobenzoxypiperidinyl)xanthine
  参考文献：
  名称：

  8-Aryl- and 8-cycloalkyl-1,3-dipropylxanthines: further potent and selective antagonists for A1-adenosine receptors

  摘要：

  A series of 1,3-dipropylxanthines were prepared with a variety of substituents at the 8-position. These included 8-aryl and 8-cycloalkyl groups. Polar carboxylate and carboxamide moieties were introduced as aryl substituents to increase water solubility. 1,3-Dipropyl-8-[2-hydroxy-4-[(carboxymethyl)oxy]phenyl]xanthine provided a functionalized congener with high potency (Ki = 37 nM) and selectivity (54-fold) for A1-adenosine receptors. This congener was used for preparation of a series of other analogues, some with higher potency and some with higher selectivity. 8-Cyclopentyl- and 8-cyclohexyl-1,3-dipropylxanthines were both very potent (Ki = 1-1.5 nM) and selective for A1 receptors, while 8-cycloalkylmethyl analogues were 10-fold less potent, but still very selective for A1 receptors. 8-Piperidinyl and 8-pyrazinyl analogues had very low activities as adenosine receptor antagonists.

  DOI：

  10.1021/jm00398a020

文献信息

• SHAMIM, M. T.;UKENA, D.;PADGETT, W. L.;HONG, O.;DALY, J. W., J. MED. CHEM., 31,(1988) N 3, 613-617
  作者：SHAMIM, M. T.、UKENA, D.、PADGETT, W. L.、HONG, O.、DALY, J. W.

  DOI：——

  日期：——