Triethyl-[(2-methylphenyl)methyl]azanium;chloride | 85267-32-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Triethyl-[(2-methylphenyl)methyl]azanium;chloride
• CAS: 85267-32-9
• 化学式: C₁₄H₂₄N*Cl
• 分子量: 241.804
• InChiKey: IHTKWLGKHZHLQL-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.38
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  一氧化碳 、 Triethyl-[(2-methylphenyl)methyl]azanium;chloride 在 dicobalt octacarbonyl sodium hydroxide 作用下， 以85%的产率得到邻甲基苯乙酸
  参考文献：
  名称：

  Sunlamp-irradiated phase-transfer catalysis. 2. Cobalt carbonyl catalyzed carbonylation of benzyltriethylammonium or allyltriethylammonium halides under 1 atm carbon monoxide

  摘要：

  DOI：

  10.1021/jo00159a031

文献信息

• [EN] PROCESS FOR PREPARING 2-EXO-(2-METHYLBENZYLOXY)-1-METHYL-4-ISOPROPYL-7-OXABICYCLO[2.2.1]HEPTANE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE 2-EXO-(2-MÉTHYLBENZYLOXY)-1-MÉTHYL-4-ISOPROPYL-7-OXABICYCLO[2.2.1]HEPTANE
  申请人：BASF AGRO BV

  公开号：WO2018177907A1

  公开（公告）日：2018-10-04

  This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) (I), any of its individual enantiomers or any non-racemic mixture thereof, comprising the step of reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) (II), any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) (III), wherein X is a leaving group, in the presence of at least one base, at least one catalyst selected from rubidium salts, cesium salts and any combination thereof and at least one inert organic solvent S1.

  该发明涉及一种制备(±)-2-外消旋-(2-甲基苄氧基)-1-甲基-4-异丙基-7-氧杂双环[2.2.1]庚烷的过程，其化学式为(I)，任何其个别对映体或其非外消旋混合物，包括以下步骤：将(±)-2-外消旋-羟基-1-甲基-4-异丙基-7-氧杂双环[2.2.1]庚烷的化学式为(II)，任何其个别对映体或其非外消旋混合物与化学式(III)的2-甲基苄基化合物反应，其中X是一个脱离基，在至少一种碱、至少一种选择自铷盐、铯盐和二者任意组合的催化剂和至少一种惰性有机溶剂S1的存在下。
• Process for preparing 2-exo-(2-methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane
  申请人：BASF Agro B.V.

  公开号：US10710969B2

  公开（公告）日：2020-07-14

  This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) any of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) wherein X is a leaving group in the presence of at least one base capable of forming water or a C1-C4 alkyl alcohol under the reaction conditions, and at least one inert organic solvent, and (b) simultaneously removing water, the C1-C4 alkyl alcohol or any mixture thereof from the reaction mixture.

  本发明涉及一种制备(±)-2-外-(2-甲基苄氧基)-1-甲基-4-异丙基-7-氧杂双环[2.2.1]庚烷的工艺，其式为(I) 其任何单个对映体或任何非外消旋混合物，包括以下步骤 (a) 使式 (II) 的(±)-2-外-羟基-1-甲基-4-异丙基-7-氧杂双环[2.2.1]庚烷反应 其任何单个对映体或其任何非外消旋混合物与式 (III) 的 2-甲基苄基化合物的混合物 其中 X 是离去基团，在至少一种在反应条件下能形成水或 C1-C4 烷醇的碱和至少一种惰性有机溶剂存在下，以及 (b) 同时从反应混合物中除去水、C1-C4 烷醇或它们的混合物。
• PROCESS FOR PREPARING 2-EXO-(2-METHYLBENZYLOXY)-1-METHYL-4-ISOPROPYL-7-OXABICYCLO[2.2.1]HEPTANE
  申请人：BASF Agro B.V.

  公开号：EP3601295A1

  公开（公告）日：2020-02-05
• Process for Preparing 2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane
  申请人：BASF Agro B.V.

  公开号：US20200031792A1

  公开（公告）日：2020-01-30

  This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (I) any of its individual enantiomers or any non-racemic mixture thereof, comprising the steps of (a) reacting (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.1]heptane of the formula (II) any of its individual enantiomers or any non-racemic mixture thereof with a 2-Methylbenzyl compound of the formula (III) wherein X is a leaving group in the presence of at least one base capable of forming water or a C 1 -C 4 alkyl alcohol under the reaction conditions, and at least one inert organic solvent, and (b) simultaneously removing water, the C 1 -C 4 alkyl alcohol or any mixture thereof from the reaction mixture.