N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxy-4-fluoroaniline | 143205-23-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: N-ethyl-N-(2-hydroxy-3-sulfopropyl)-3,5-dimethoxy-4-fluoroaniline
• 英文别名: 3-(N-ethyl-4-fluoro-3,5-dimethoxyanilino)-2-hydroxypropane-1-sulfonic acid
• CAS: 143205-23-6
• 化学式: C₁₃H₂₀FNO₆S
• 分子量: 337.369
• InChiKey: DHOHNBDXAQUXGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• METHOD FOR MEASURING TRIGLYCERIDE IN LOW-DENSITY LIPOPROTEIN AND KIT FOR MEASUREMENT
  申请人：Katayama Yuki

  公开号：US20090226944A1

  公开（公告）日：2009-09-10

  The present invention provides a method for a simple and accurate measurement of triglycerides in low-density lipoprotein in a sample comprising performing the following steps sequentially: (i) a step of generating free glycerol by allowing lipoprotein lipase to act on a sample, in an aqueous medium comprising the sample and a specific surfactant such as polyoxyethylene polyoxyalkylene polycyclic phenyl ether; (ii) a step of removing free glycerol present in the reaction solution of the above step (i); (iii) a step of generating free glycerol by allowing lipoprotein lipase to act on the reaction solution from which free glycerol has been removed in step (ii), in the presence of a specific surfactant such as polyoxyethylene polyoxyalkylene alkyl ether; and (iv) a step of measuring free glycerol generated in step (iii), and a kit used for the method.

  本发明提供了一种简单准确地测量样品中低密度脂蛋白中甘油三酯的方法，包括按照以下步骤顺序进行：(i)在包括样品和特定表面活性剂（例如聚氧乙烯聚氧烷基多环苯醚）的水介质中，使脂蛋白酯酶作用于样品，生成游离甘油；(ii)去除步骤(i)中反应溶液中存在的游离甘油；(iii)在去除步骤(ii)中的游离甘油的反应溶液中，使脂蛋白酯酶作用于特定表面活性剂（例如聚氧乙烯聚氧烷基烷基醚）的存在下，生成游离甘油；(iv)测量步骤(iii)中生成的游离甘油，以及用于该方法的试剂盒。
• OXIDATIVE CHROMOGENIC COMPOUND OR SALT THEREOF AND PRODUCTION METHOD THEREOF, AND REAGENT COMPOSITION AND TEST INSTRUMENT USING THE SAME
  申请人：Kawanishi Tetsuro

  公开号：US20100062464A1

  公开（公告）日：2010-03-11

  It is an object of the present invention to provide a means for measuring a concentration of various components rapidly with high accuracy and high sensitivity. The present invention is to provide an oxidative chromogenic compound or salt thereof represented by the following chemical formula (1): wherein R 1 and R 2 are each independently a linear or branched alkyl group having 1 to 5 carbon atoms; R 3 , R 4 , R 5 , R 6 and R 7 are each independently a hydrogen atom, a carboxyl group or a sulfonic acid group, or salt thereof, provided that at least one of R 3 to R 7 is a carboxyl group or a sulfonic acid group, or salt thereof, and the others are hydrogen atoms, and the production method thereof, and the reagent composition and test instrument using the same.

  本发明的目的是提供一种快速、高精度和高灵敏度测量各种成分浓度的手段。本发明提供了一种氧化性显色化合物或其盐，其化学式如下（1）：其中R1和R2分别是具有1至5个碳原子的线性或支链烷基；R3、R4、R5、R6和R7分别是氢原子、羧基或磺酸基，或其盐，但至少其中之一是羧基或磺酸基，或其盐，其余为氢原子，以及其生产方法、试剂组成和使用该试剂组成的测试仪器。
• Oxidizable color producing reagent
  申请人：WAKO PURE CHEMICAL INDUSTRIES LTD

  公开号：EP0488756A1

  公开（公告）日：1992-06-03

  The amount of an oxidative substance or a peroxidase-like substance can be determined by using a combined color former comprising 4-aminoantipyrine or a derivative thereof, etc., as a main color former and a p-fluoroaniline derivative or a salt thereof as a color producing component.

  氧化物质或过氧化物酶样物质的量可通过使用组合显色剂来确定，组合显色剂包括作为主显色剂的 4-氨基安替比林或其衍生物等，以及作为显色成分的对氟苯胺衍生物或其盐。
• Method for measuring an amount of LDL-cholesterol
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD

  公开号：EP0821239A2

  公开（公告）日：1998-01-28

  The present invention is to provide a method for measuring an amount of cholesterol in low density lipoproteins (LDL-cholesterol) in a sample specifically at high accuracy and a reagent used in this method, and the present invention can attain such effect that direct measuring an amount of LDL-cholesterol by widely used automatic analyzers can be conducted by using the invention, which has not been possible after known methods.

  本发明旨在提供一种高精度测量样本中低密度脂蛋白（LDL-胆固醇）中胆固醇含量的方法以及该方法中使用的试剂，本发明可以达到这样的效果，即使用本发明可以通过广泛使用的自动分析仪直接测量 LDL-胆固醇的含量，这是已知方法无法实现的。
• Measurement of LDL-cholesterol
  申请人：WAKO PURE CHEMICAL INDUSTRIES, LTD

  公开号：EP0878716A1

  公开（公告）日：1998-11-18

  Cholesterol in low density lipoproteins can be measured specifically and precisely using directly an autoanalyzer in the presence of an amphoteric surfactant and at least one member selected from cyclodextrin and derivatives thereof.

  低密度脂蛋白中的胆固醇可在两性表面活性剂和至少一种选自环糊精及其衍生物的成分存在下，直接使用自动分析仪进行特异性和精确的测量。