2,12-diaminododecanoic acid | 113417-80-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,12-diaminododecanoic acid
• CAS: 113417-80-4
• 化学式: C₁₂H₂₆N₂O₂
• 分子量: 230.351
• InChiKey: YKELVKGOSDUOCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  89.3
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] FORMULATION AND METHOD OF PREPARATION<br/>[FR] FORMULATION ET PROCÉDÉ DE PRÉPARATION
  申请人：GE HEALTHCARE AS

  公开号：WO2019185607A1

  公开（公告）日：2019-10-03

  There is described formulations for human or animal administration and to a method of preparation thereof. In particular, there is described more stable pharmaceutical formulations, such as those for intravenous administration, and to a method of preparation thereof. There are also described lyophilised formulations having an active pharmaceutical ingredient (API), a buffering agent and a lyoprotectant, wherein the API is an imaging agent comprising at least one cMet binding peptide, suitable for optically imaging the mammalian body in vivo. Also described are a method of preparing a lyophilised formulation, a pharmaceutical composition, and a kit for the preparation of the pharmaceutical composition. Further described are methods of imaging using the formulation or pharmaceutical composition, such as in detection, diagnosis, surgery, staging, treatment, monitoring of treatment, monitoring of disease progression or monitoring therapy of conditions such as cancer.

  描述了用于人类或动物给药的配方以及其制备方法。特别是，描述了更稳定的药物配方，例如用于静脉给药的配方，以及其制备方法。还描述了冻干配方，其中包含一种活性药物成分（API）、缓冲剂和冻干保护剂，其中API是包含至少一种cMet结合肽的成像剂，适用于体内光学成像哺乳动物体。还描述了制备冻干配方的方法、药物组合物和用于制备药物组合物的工具包。此外，还描述了使用该配方或药物组合物进行成像的方法，例如在癌症的检测、诊断、手术、分期、治疗、治疗监测、疾病进展监测或治疗监测等方面。
• HEAT RESISTANT POLYAMIDE COMPOSITION AND APPLICATION THEREOF
  申请人：Kingfa Sci. & Tech. Co., Ltd.

  公开号：EP2703449B1

  公开（公告）日：2016-06-29
• FORMULATION AND METHOD OF PREPARATION
  申请人：GE Healthcare AS

  公开号：EP3773750A1

  公开（公告）日：2021-02-17
• COMPOUNDS AND METHODS OF USE
  申请人：Edinburgh Molecular Imaging Limited

  公开号：EP3983019A1

  公开（公告）日：2022-04-20
• Heat-Resistant Polyamide Composition and Application Thereof
  申请人：Yi Qingfeng

  公开号：US20140303293A1

  公开（公告）日：2014-10-09

  The present invention discloses a heat-resistant polyamide composition and application thereof. The composition comprises the following components in percentage by weight: 40% to 90% of heat-resistant polyamide resin, 5% to 35% of mineral fiber A, 0 to 35% of mineral filler B, 0.1% to I% of light stabilizer, 0.1% to 1% of flow modifier and 0.1% to 1% of antioxidant. In the present invention, heat-resistant polyamide resin with the ratio of amine-terminated group and carboxyl-terminated group between 0.1 and 0.8 is selected to be matched with deformed glass fibers with an aspect ratio of 2 to 6, the mineral filler B and the flow modifier to obtain the heat-resistant polyamide composition. The heat-resistant polyamide composition not only has high initial whiteness, high reflectivity and excellent heat resistance, but also has good moldability and good dimensional stability; therefore, the heat-resistant polyamide composition is capable of being applied for preparing the reflecting supports for s toll light sources as LCD backlight of portable phones, computers, televisions and the like, as well as headlights of automotive vehicles, instrument panels and lighting appliances, etc.