(Ξ)-malic acid-1-ξ-D-glucopyranosyl ester | 123128-58-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (Ξ)-malic acid-1-ξ-D-glucopyranosyl ester
• 英文别名: (Ξ)-Aepfelsaeure-1-ξ-D-glucopyranosylester；3-hydroxy-4-oxo-4-[(3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybutanoic acid
• CAS: 123128-58-5
• 化学式: C₁₀H₁₆O₁₀
• 分子量: 296.231
• InChiKey: BGJISNGZGIODCS-KTRFCHCSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  174
• 氢给体数：
  6
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  苹果酸 、 葡萄糖 在 水 作用下， 生成 (Ξ)-malic acid-1-ξ-D-glucopyranosyl ester
  参考文献：
  名称：

  Elevation of Serum Pro-Gastrin - Releasing Peptide in Patients with Medullary Thyroid Carcinoma and Small Cell Lung Carcinoma

  摘要：

  Medullary thyroid carcinoma (MTC) arises from parafollicular or C cells of the thyroid gland and produces a variety of peptides such as calcitonin (CT) and gastrin-releasing peptide (GRP). Here we measured serum levels of pro-gastrin-releasing peptide (Pro-GRP), a more stable precursor of GRP, in 15 patients with MTC (4 males, 11 females) who did not show any clinical or radiologic signs of small cell lung cancer. Serum Pro-GRP levels were elevated in 80% (12/15) patients. Significant correlation was observed between serum Pro-GRP and CT (r = 0.52) and carcinoembryonic antigen (CEA) (r = 0.56). Serum Pro-GRP levels also correlated with tumor size (r = 0.70). Serum Pro-GRP levels also decreased below the cut-off range in one patient after surgical resection. Our data suggest that Pro-GRP, which is considered to be a specific marker for small cell lung carcinoma, seems to be also helpful and additional marker for the diagnosis and monitoring the response to therapy in patients with MTC in addition to calcitonin as the main tumor marker.

  DOI：

  10.1089/105072501753271752

文献信息

• [EN] HEXOSE DERIVATIVES, PREPARATION AND USES THEREOF<br/>[FR] DÉRIVÉS D'HEXOSE, LEUR PRÉPARATION ET UTILISATIONS
  申请人：EXTREMOCHEM LDA

  公开号：WO2015137838A1

  公开（公告）日：2015-09-17

  A compound of formula I : or a salt thereof, wherein: R1 is -OC(H) (X) (CH2)nC(=O)OH; R2 is -OH, -N3, or -N (H) C (=O) CH3; or R1 and R2 together with the carbon atoms to which they are attached form R3 is -H, -CH3, -CH2C(=O)OH, or -CH2OH; X is -H, -CH3, -CH2OH, or CH2C(=O)OH; and n is 0 or 1.

  一个化合物的化学式I：或其盐，其中：R1为-OC(H)(X)(CH2)nC(=O)OH；R2为-OH，-N3或-N(H)C(=O)CH3；或R1和R2与它们连接的碳原子一起形成R3为-H，- ，- C(=O)OH或- OH；X为-H，- ，- OH或 C(=O)OH；n为0或1。
• HEXOSE DERIVATIVES, PREPARATION AND USES THEREOF
  申请人：Faculdade De Ciências da Universidade de Lisboa

  公开号：EP3116886A1

  公开（公告）日：2017-01-18