(1,2-ethanediamine-N,N')[2-(2'-pyridyl)phenyl-N',C]palladium(1+) chloride | 117958-64-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (1,2-ethanediamine-N,N')[2-(2'-pyridyl)phenyl-N',C]palladium(1+) chloride
• 英文别名: (2-phenylpyridinato-C**2,N')(ethylenediamine)palladium(II) chloride；[(2-phenylpyridinato)(ethylenediamine)palladium(II)] chloride；[Pd(C5H4NC6H4)(ethylenediamine)]Cl；[(2-phenylpyridine(-1H))Pd(en)][Cl]；[(2-phenylpyridine(-1H))Pd(ethylenediamine)][Cl]
• CAS: 117958-64-2
• 化学式: C₁₃H₁₆N₃Pd*Cl
• 分子量: 356.163
• InChiKey: QIYGQSRYDPNBSS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  氟硼酸钠 、 (1,2-ethanediamine-N,N')[2-(2'-pyridyl)phenyl-N',C]palladium(1+) chloride 以 水 、 丙酮 为溶剂， 生成 (2-phenylpyridinato-C**2,N')(ethylenediamine)palladium(II) BF4
  参考文献：
  名称：

  Craig, Carl A.; Watts, Richard J., Inorganic Chemistry, 1989, vol. 28, # 2, p. 309 - 313

  摘要：

  DOI：
• 作为产物：
  描述：

  di-μ-chlorobis{(2-phenylpyridine)palladium(II)} 在 乙二胺 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到(1,2-ethanediamine-N,N')[2-(2'-pyridyl)phenyl-N',C]palladium(1+) chloride
  参考文献：
  名称：

  Craig, Carl A.; Watts, Richard J., Inorganic Chemistry, 1989, vol. 28, # 2, p. 309 - 313

  摘要：

  DOI：

文献信息

• Effect of charge and surface area on the cytotoxicity of cationic metallointercalation reagents
  作者：Gavin L Edwards、David St.C Black、Glen B Deacon、Laurence PG Wakelin

  DOI：10.1139/v05-110

  日期：2005.6.1

  Reaction of a series of nitrogen donor ligands (1-phenylpyrazoles, 2-phenylpyridine, benzo[h]quinoline, 1-(2′-pyridyl)indole, 1-phenylindazole, and 2-phenylindazole) with palladium(II) and platinum(II) salts gave complexes where ortho-metallation had occurred resulting in bidentate binding to the metal centres through N and C atoms. These cyclometallated products were isolated as µ-chloro dimers. Subsequent treatment of these µ-chloro dimers with chelating diamines such as 1,2-ethanediamine converted them into 14 cationic (1+) complexes. Analogous coordination mixed ligand complexes (charge 2+) were prepared by reaction of dichloro(1,2-ethanediamine-N,N′)palladium(II) with aromatic diamines such as 2-(1′-pyrazolyl)pyridine, 2,2′-bipyridine, and 1,10-phenanthroline. The complexes exhibited growth inhibitory activity against L1210 mouse leukæmia cells in vitro over a wide concentration range; in general, the cyclometallated complexes were more active than the mixed ligand complexes, although one cyclometallated organoplatinum complex was less active than the mixed ligand analogue. Substitution around the periphery of the aromatic ligands also resulted in increased activity. One complex, derived from 1-(2'-pyridyl)indole, was tested in vivo and showed no significant antitumour inhibition against P388 leukæmia at doses below toxic levels. Key words: anticancer, metallointercalator, cyclometallation, palladium, platinum, cytotoxicity.

  一系列氮配体供体（1-苯基吡唑，2-苯基吡啶，苯并[h]喹啉，1-(2'-吡啶基)吲哚，1-苯基吲唑和2-苯基吲唑）与钯（II）和铂（II）盐发生反应，形成了通过N和C原子在金属中心上双齿结合的配合物，其中发生了邻位金属化反应。这些环金属化产物被分离为µ-氯二聚体。随后，将这些µ-氯二聚体与螯合二胺（如1,2-乙二胺）处理，将它们转化为14个阳离子（+1）配合物。通过将二氯（1,2-乙二胺-N,N'）钯（II）与芳香二胺（如2-(1'-吡唑基)吡啶，2,2'-联吡啉和1,10-邻菲啰啉）反应，制备了类似的配位混合配体配合物（+2）。这些配合物在体外对L1210小鼠白血病细胞表现出一定浓度范围内的生长抑制活性；一般而言，环金属化配合物比混合配体配合物更活跃，尽管一个环金属化有机铂配合物的活性低于混合配体类似物。芳香配体周围的取代也导致了活性增加。从1-(2'-吡啶基)吲哚衍生的一个配合物在体内测试，显示在低于毒性水平的剂量下对P388白血病没有显著的抗肿瘤抑制作用。关键词：抗癌，金属插层剂，环金属化，钯，铂，细胞毒性。
• Balashev; Puzyk; Khanukaeva, Russian Journal of General Chemistry, 1998, vol. 68, # 10, p. 1670 - 1671
  作者：Balashev、Puzyk、Khanukaeva、Antonov、Ivanov

  DOI：——

  日期：——
• ——
  作者：K. P. Balashev、Yu. A. Ivanov、T. V. Taraskina、E. A. Cherezova

  DOI：10.1023/a:1019584908205

  日期：——