2-phenyl-4-(phenylethynyl)pyridine | 1351991-76-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-phenyl-4-(phenylethynyl)pyridine
• 英文别名: 4-phenylethynyl-2-phenylpyridine；2-Phenyl-4-(2-phenylethynyl)pyridine；2-phenyl-4-(2-phenylethynyl)pyridine
• CAS: 1351991-76-8
• 化学式: C₁₉H₁₃N
• 分子量: 255.319
• InChiKey: VRBSRBZJHWFBTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  在 四氯苯醌 、 溶剂黄146 作用下， 生成 2-phenyl-4-(phenylethynyl)pyridine
  参考文献：
  名称：

  Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acyl-2,3-dihydropyridones

  摘要：

  We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acy1-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2015.07.045

文献信息

• Two-photon spectroscopy of cyclometalated iridium complexes
  作者：Robert M. Edkins、Sylvia L. Bettington、Andrés E. Goeta、Andrew Beeby

  DOI：10.1039/c1dt11164g

  日期：——

  The near-infrared two-photon absorption (TPA) spectra of a series of cyclometalated iridium complexes have been measured. These complexes exhibit moderately large TPA cross-sections of approximately 20 GM at the biological relevant wavelength of 800 nm. A new complex has been designed and synthesised, and found to have an increased cross-section of 44 GM at 800 nm. Full photophysical characterisation of this complex is presented.

  近红外双光子吸收（TPA）光谱已测定了一系列环金属化铱配合物的数据。这些配合物在800纳米生物相关波长下展现出中等大小的双光子吸收截面，约20 GM。设计并合成了一种新配合物，该配合物在800纳米处的截面提高至44 GM。本文展示了该配合物的完整光物理表征。
• Synthesis of substituted pyridines from 1,2-nucleophilic addition products of functionalized N-acyl-2,3-dihydropyridones
  作者：Mustafa Guzel、Joshua Watts、Matthew McGilvary、Marcus Wright、Sezgin Kiren

  DOI：10.1016/j.tetlet.2015.07.045

  日期：2015.9

  We describe herein a general and efficient synthetic approach toward substituted pyridines from functionalized N-acy1-2,3-dihydropyridones in two steps; 1,2-addition with organocerium reagents and subsequent oxidative aromatization with chloranil. This strategy allows the generation of pyridines with various substitution patterns and introduces a variety of substituents including aryl, alkyl, alkynyl, alkenyl, and heteroaryl groups at the desired positions. Published by Elsevier Ltd.