5-methyl-3-phenyl-1'-(phenylsulfonyl)-2,3'-biindole | 1309467-12-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 5-methyl-3-phenyl-1'-(phenylsulfonyl)-2,3'-biindole
• 英文别名: 2-[1-(benzenesulfonyl)indol-3-yl]-5-methyl-3-phenyl-1H-indole
• CAS: 1309467-12-6
• 化学式: C₂₉H₂₂N₂O₂S
• 分子量: 462.572
• InChiKey: JHEFYVMURHSRNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.03
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  在 PPA 作用下， 以 甲苯 为溶剂， 生成 5-methyl-3-phenyl-1'-(phenylsulfonyl)-2,3'-biindole
  参考文献：
  名称：

  A convenient Fischer indole synthesis of 2,3′-biindoles

  摘要：

  Both symmetrical and unsymmetrical 2,3'-biindoles are efficiently synthesized in good to excellent yields by Fischer indole synthesis. The scope of the method was evaluated by examining substituent effects with para-substituted hydrazines and 3-acylindoles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.049

文献信息

• A convenient Fischer indole synthesis of 2,3′-biindoles
  作者：Philip E. Alford、Liangfeng Fu、Joseph K. Kubert、Lingshan Wang、Gordon W. Gribble

  DOI：10.1016/j.tetlet.2011.03.049

  日期：2011.5

  Both symmetrical and unsymmetrical 2,3'-biindoles are efficiently synthesized in good to excellent yields by Fischer indole synthesis. The scope of the method was evaluated by examining substituent effects with para-substituted hydrazines and 3-acylindoles. (C) 2011 Elsevier Ltd. All rights reserved.