3-Hydroxy-6-methyl-2-dimethylaminomethyl-4H-pyran-4-one-HCl | 188116-21-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3-Hydroxy-6-methyl-2-dimethylaminomethyl-4H-pyran-4-one-HCl
• 英文别名: 2-[(Dimethylamino)methyl]-3-hydroxy-6-methylpyran-4-one;hydrochloride
• CAS: 188116-21-4
• 化学式: C₉H₁₃NO₃*ClH
• 分子量: 219.668
• InChiKey: WXFRKAVLIBPPIG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.14
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  49.8
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• DRUG FOR AMELIORATING BRAIN DISEASES
  申请人：WAKUNAGA PHARMACEUTICAL CO., LTD.

  公开号：EP0838220A1

  公开（公告）日：1998-04-29

  The present invention discloses a drug for ameliorating brain diseases which comprises as an active ingredient a compound represented by the following formula (1): [wherein R1 represents H, OH, a lower alkoxyl group, or a lower alkyl group; each of R2 and R3 represents H, a (substituted) lower alkyl group, a lower alkenyl group, a (substituted) phenyl group, or a (substituted) styryl group; and X represents O or a nitrogen atom which may be substituted by a lower alkyl group] or a salt thereof. Because of inhibiting a decrease in brain neurons and promoting branching of neurites, this drug is efficacious in the prevention and treatment of dementia, etc. in association with degeneration and sloughing of brain neurons.

  本发明公开了一种用于改善脑部疾病的药物，其活性成分包括下式（1）所代表的化合物： [其中 R1 代表 H、OH、低级烷氧基或低级烷基；R2 和 R3 各代表 H、（取代的）低级烷基、低级烯基、（取代的）苯基或（取代的）苯乙烯基；X 代表 O 或可被低级烷基取代的氮原子]或其盐。由于这种药物能抑制脑神经元的减少并促进神经元的分枝，因此对预防和治疗与脑神经元退化和脱落有关的痴呆症等具有疗效。
• US5962480A
  申请人：——

  公开号：US5962480A

  公开（公告）日：1999-10-05