4-amino-2-methyl-2-phenyl-1,2-dihydropyrimido[1,2-a]benzimidazole-3-carbonitrile | 1083171-77-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 4-amino-2-methyl-2-phenyl-1,2-dihydropyrimido[1,2-a]benzimidazole-3-carbonitrile
• CAS: 1083171-77-0
• 化学式: C₁₈H₁₅N₅
• 分子量: 301.351
• InChiKey: TZFRBKBDESVPJY-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-氨基苯并咪唑 、 苯乙酮 、 丙二腈 以 水 为溶剂， 以79%的产率得到4-amino-2-methyl-2-phenyl-1,2-dihydropyrimido[1,2-a]benzimidazole-3-carbonitrile
  参考文献：
  名称：

  Versatility of Alternative Reaction Media: Water-Mediated Domino and Green Chemical Synthesis of Pyrimido[1,2-a]benzimidazole Under Nonconventional Conditions

  摘要：

  A convenient and clean water-mediated synthesis of a series of 4-amino-2-aryl-1,2-dihydro pyrimido[1,2-a]benzimidazoles (4) is reported using alternative nonconventional energy sources. The products are obtained in shorter times with excellent yields (78-89%) from the multicomponent reaction of 2-aminobenzimidazole (1), malononitrile/ethylcyanoacetate (2a/b), and carbonyl compounds (3). The reaction is found to be general with respect to the cyclic and acyclic carbonyl compounds. The procedure does not involve the use of any additional reagent/catalyst, produces no waste, and represents a green synthetic protocol with high atom economy.

  DOI：

  10.1080/00397910802164732