3-Chloro-1-(cyclopropylmethyl)-4-[4-(4-morpholin-4-ylphenyl)piperidin-1-yl]pyridin-2-one | 1127498-37-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-Chloro-1-(cyclopropylmethyl)-4-[4-(4-morpholin-4-ylphenyl)piperidin-1-yl]pyridin-2-one
• CAS: 1127498-37-6
• 化学式: C₂₄H₃₀ClN₃O₂
• 分子量: 427.974
• InChiKey: XVTLFBQDIXVAJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  36
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE
  申请人：Janssen Pharmaceutica NV

  公开号：EP3424535A1

  公开（公告）日：2019-01-09

  The present invention relates to combinations comprising a positive allosteric modulator ("PAM") of metabotropic glutamatergic receptor subtype 2 ("mGluR2") or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A ("SV2A") ligand.

  本发明涉及由代谢谷氨酸能受体亚型 2（"mGluR2"）的正异位调节剂（"PAM"）或其药学上可接受的盐或溶液，或代谢谷氨酸能受体亚型 2 化合物的正异位激动剂或其药学上可接受的盐或溶液和突触囊泡蛋白 2A（"SV2A"）配体组成的组合。
• Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
  申请人：Janssen Pharmaceutica NV

  公开号：US11369606B2

  公开（公告）日：2022-06-28

  The present invention relates to combinations comprising a positive allosteric modulator (“PAM”) of metabotropic glutamatergic receptor subtype 2 (“mGluR2”) or a pharmaceutically acceptable salt or a solvate thereof, or an orthosteric agonist of metabotropic glutamatergic receptor subtype 2 compound or a pharmaceutically acceptable salt or a solvate thereof, and a synaptic vesicle protein 2A (“SV2A”) ligand.

  本发明涉及由代谢谷氨酸能受体亚型 2（"mGluR2"）的正异位调节剂（"PAM"）或其药学上可接受的盐或溶液，或代谢谷氨酸能受体亚型 2 化合物的正异位激动剂或其药学上可接受的盐或溶液和突触囊泡蛋白 2A（"SV2A"）配体组成的组合。