Ac-(5H-Dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leu-asp-ile-ile-trp) | 153049-49-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-(5H-Dibenzyl(a,d)cycloheptene-10,11-dihydroglycine-leu-asp-ile-ile-trp)
• 英文别名: (3S)-3-[[(2S)-2-[[(2R)-2-acetamido-2-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenyl)acetyl]amino]-4-methylpentanoyl]amino]-4-[[(2S,3S)-1-[[(2S,3S)-1-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
• CAS: 153049-49-1
• 化学式: C₅₂H₆₇N₇O₁₀
• 分子量: 950.1
• InChiKey: HRAQSWKGRRUBDJ-OMUAVVNCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  69
• 可旋转键数：
  23
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  265
• 氢给体数：
  9
• 氢受体数：
  10

文献信息

• METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES BY INHIBITING ENDOTHELIN RECEPTORS
  申请人：Board of Regents, The University of Texas System

  公开号：US20150182583A1

  公开（公告）日：2015-07-02

  Compositions and methods of treatment of tauopathies are provided. In some embodiments, an antagonist of endothclin receptor A (ETA) and endothelin receptor B (ETB) may be administered to a subject to reduce tau production or accumulation, e.g., in astrocytes. The antagonist may be a dual ETA and ETB receptor antagonist. In some aspects, methods are provided for the treatment of chemo-brain, hypoxia, brain ischemia, surgical dementia, glioblastoma, or a traumatic brain injury (TBI).
• [EN] METHODS FOR TREATMENT AND PREVENTION OF TAUOPATHIES BY INHIBITING ENDOTHELIN RECEPTORS<br/>[FR] MÉTHODES DE TRAITEMENT ET DE PRÉVENTION DE TAUOPATHIES PAR L'INHIBITION DE RÉCEPTEURS DE L'ENDOTHÉLINE
  申请人：UNIV TEXAS

  公开号：WO2014025837A1

  公开（公告）日：2014-02-13

  Compositions and methods of treatment of tauopathies are provided. In some embodiments, an antagonist of endothelin receptor A (ETA) and endothelin receptor B (ETB) may be administered to a subject to reduce tau production or accumulation, e.g., in astrocytes. The antagonist may be a dual ETA and ETB receptor antagonist. In some aspects, methods are provided for the treatment of chemo-brain, hypoxia, brain ischemia, surgical dementia, glioblastoma, or a traumatic brain injury (TBI).