hexyne-1,6-dicarboxylic acid | 121822-89-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: hexyne-1,6-dicarboxylic acid
• 英文别名: Oct-2-ynedioic acid
• CAS: 121822-89-7
• 化学式: C₈H₁₀O₄
• 分子量: 170.165
• InChiKey: PXMPJJIXWLEXEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• ALIGNING AGENT FOR LIQUID CRYSTAL
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP0980016A1

  公开（公告）日：2000-02-16

  The present invention relates to a treating agent for liquid crystal alignment, which is an agent for liquid crystal alignment to be used for a method in which polarized ultraviolet rays or electron rays are irradiated on a polymer thin film formed on a substrate in a predetermined direction relative to the substrate plane, and said substrate is used for aligning liquid crystal without rubbing treatment, wherein said agent for liquid crystal alignment contains a polymer compound having photochemically reactive groups in the polymer main chain and a glass transition temperature of at least 200°C.

  本发明涉及一种用于液晶配向的处理剂，它是一种用于液晶配向的处理剂，在该方法中，偏振紫外线或电子射线按相对于基底平面的预定方向照射在基底上形成的聚合物薄膜上，所述基底用于配向液晶而无需摩擦处理，其中所述液晶配向剂含有一种聚合物化合物，该聚合物化合物在聚合物主链中具有光化学反应基团，玻璃化温度至少为 200°C。
• BENZAMIDE COMPOUND AND PREPARATION METHOD, USE, AND PHARMACEUTICAL COMPOSITION THEREOF
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：EP3747866A1

  公开（公告）日：2020-12-09

  The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

  本发明涉及一种苯甲酰胺化合物及其制备方法、用途和药物组合物。由式（I）代表的苯甲酰胺化合物是一种 STAT3 抑制剂，可用于预防和/或治疗与 STAT3 活性有关的疾病，如肿瘤、自身免疫性疾病、肾脏疾病、心血管疾病、炎症、代谢/内分泌功能障碍和神经系统疾病。
• Complexes and salts of dihydropyrimidine derivatives and their application in pharmaceuticals
  申请人：SUNSHINE LAKE PHARMA CO., LTD.

  公开号：US10098889B2

  公开（公告）日：2018-10-16

  This invention relates to L-tartaric acid complexes, acid addition salts, base addition salts of the compound named (S)-4-(((R)-6-(2-chloro-4-fluorophenyl)-5-(methoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl) morpholine-3-carboxylic acid or tautomer thereof and pharmaceutical compositions thereof, and further relates to use of the compounds or the pharmaceutical compositions in the manufacture of a medicament, especially for use in preventing, managing, treating or lessening a HBV infection. The complex, acid addition salt or base addition salt of the present invention is crystalline form, substantially crystalline form, polymorphism, amorphism, hydrate or solvate.

  本发明涉及名为(S)-4-(((R)-6-(2-氯-4-氟苯基)-5-(甲氧羰基)-2-(噻唑-2-基)-3,6-二氢嘧啶-4-基)甲基)吗啉-3-羧酸或其同系物的L-酒石酸复合物、酸加成盐、碱加成盐及其药物组合物、并进一步涉及这些化合物或药物组合物在制造药物中的用途，特别是在预防、控制、治疗或减轻 HBV 感染中的用途。本发明的复合物、酸加成盐或碱加成盐是晶体状、基本晶体状、多晶体、非晶体、水合物或溶液。
• Salt of substituted urea derivative and use thereof in medicine
  申请人：SUNSHINE LAKE PHARMA CO. LTD.

  公开号：US11213529B2

  公开（公告）日：2022-01-04

  A salt of a substituted urea derivative of formula (I) and use thereof in the pharmaceutical field. Also, a pharmaceutical composition containing the salt or a combination thereof, and use of the salt or the pharmaceutical composition in the manufacture of a medicament for treating, remitting or preventing a disorder related to tyrosine kinase activity.

  一种式（I）的取代脲衍生物的盐及其在制药领域的用途。此外，一种含有该盐或其组合物的药物组合物，以及该盐或该药物组合物在制造治疗、缓解或预防与酪氨酸激酶活性有关的疾病的药物中的用途。
• Benzamide compound and preparation method, use, and pharmaceutical composition thereof
  申请人：INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES

  公开号：US11518744B2

  公开（公告）日：2022-12-06

  The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

  本发明涉及一种苯甲酰胺化合物及其制备方法、用途和药物组合物。由式（I）代表的苯甲酰胺化合物是一种 STAT3 抑制剂，可用于预防和/或治疗与 STAT3 活性有关的疾病，如肿瘤、自身免疫性疾病、肾脏疾病、心血管疾病、炎症、代谢/内分泌功能障碍和神经系统疾病。