N-o-Chlorbenzyl-N-methylaminoaethanol | 17683-37-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-o-Chlorbenzyl-N-methylaminoaethanol
• 英文别名: 2-[(2-chloro-benzyl)-methyl-amino]-ethanol；2-[(2-Chlor-benzyl)-methyl-amino]-aethanol；N-(2-chlorobenzyl)-N-methylethanolamine；2-[(2-chlorophenyl)methyl-methylamino]ethanol
• CAS: 17683-37-3
• 化学式: C₁₀H₁₄ClNO
• mdl: MFCD14646022
• 分子量: 199.68
• InChiKey: VNAJSFYPTISPBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-o-Chlorbenzyl-N-methylaminoaethanol 在 氨 、 镍 作用下， 生成 [2-(3-amino-propoxy)-ethyl]-(2-chloro-benzyl)-methyl-amine
  参考文献：
  名称：

  The Synthesis of Bis-quaternary Salts of Some 1,7-Phenanthroline Derivatives

  摘要：

  DOI：

  10.1021/ja01648a046
• 作为产物：
  描述：

  N-甲基-2-氯苄胺 、 2-氯乙醇 生成 N-o-Chlorbenzyl-N-methylaminoaethanol
  参考文献：
  名称：

  The Synthesis of Bis-quaternary Salts of Some 1,7-Phenanthroline Derivatives

  摘要：

  DOI：

  10.1021/ja01648a046

文献信息

• 2-(aminoalkoxy) phenylalkylamines with antiinflammatory activity
  申请人：Knoll Aktiengesellschaft

  公开号：US05736568A1

  公开（公告）日：1998-04-07

  Compounds of the formula I ##STR1## including pharmaceutically acceptable salts thereof are disclosed in which R.sub.1, R.sub.2, R.sub.3, and R.sub.4 independently represent hydrogen, hydroxy, halo, halogenated alkyl, halogenated alkoxy, alkyl, alkoxy, cyano, a carbamoyl group, carbonyl group, or R.sub.1 and R.sub.2 together with the phenyl ring represent a naphthalene ring (optionally substituted); L.sub.1 represents C.sub.2-6 alkylene; R.sub.5 represents hydrogen or alkyl, R.sub.6 represents hydrogen or alkyl, phenylalkyl (optionally substituted) or R.sub.5 and R.sub.6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring; L.sub.2 represents a C.sub.1-6 alkylene chain; and R.sub.7 and R.sub.8 independently represent hydrogen or alkyl or R.sub.7 and R.sub.8 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring. The compounds are anti-inflammatory and/or anti-allergic agents and/or immunomodulants useful in treating rheumatic diseases and/or neurological damage. Compositions containing these compounds and processes to make then are also disclosed.

  公开了具有以下结构的化合物的药学可接受的盐，其中R.sub.1、R.sub.2、R.sub.3和R.sub.4分别表示氢、羟基、卤素、卤代烷基、卤代烷氧基、烷基、烷氧基、氰基、氨基甲酰基、羰基，或R.sub.1和R.sub.2与苯环一起表示一个萘环（可选择性地取代）；L.sub.1表示C.sub.2-6烷基；R.sub.5表示氢或烷基，R.sub.6表示氢或烷基，苯基烷基（可选择性地取代）或R.sub.5和R.sub.6与它们连接的氮原子一起表示饱和的3-7成员杂环；L.sub.2表示C.sub.1-6烷基链；R.sub.7和R.sub.8独立地表示氢或烷基，或R.sub.7和R.sub.8与它们连接的氮原子一起表示饱和的3-7成员杂环。这些化合物是抗炎症和/或抗过敏剂和/或免疫调节剂，可用于治疗风湿性疾病和/或神经损伤。还公开了含有这些化合物的组合物和制备它们的方法。
• Hypotensive Agents. II. Aminoalkyl Esters of Piperidinecarboxylic Acids and Their “Reversed” Ester Derivatives
  作者：John H. Biel、Edwin P. Sprengeler、Harris L. Friedman

  DOI：10.1021/ja01580a021

  日期：1957.12
• 2-(AMINOALKOXY)PHENYLALKYLAMINES WITH ANTIINFLAMMATORY ACTIVITY
  申请人：Knoll AG

  公开号：EP0750607A1

  公开（公告）日：1997-01-02
• US5736568A
  申请人：——

  公开号：US5736568A

  公开（公告）日：1998-04-07
• [EN] 2-(AMINOALKOXY)PHENYLALKYLAMINES WITH ANTIINFLAMMATORY ACTIVITY<br/>[FR] 2-(AMINOALCOXY)PHENYLALCOYLAMINES PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE
  申请人：KNOLL AG

  公开号：WO1995023127A1

  公开（公告）日：1995-08-31

  (EN) Compounds of formula (I) including pharmaceutically acceptable salts thereof in which R1, R2, R3, and R4 independently represent hydrogen, hydroxy, halo, halogenated alkyl, halogenated alkoxy, alkyl, alkoxy, cyano, a carbamoyl group of formula CONRARB, alkoxy carbonyl group, or R1 and R2 together with the phenyl ring represent a naphthalene ring (optionally substituted); L1 represents C2-6 alkylene optionally substituted by one or more C1-4 alkyl groups; R5 represents hydrogen or alkyl, R6 represents hydrogen or alkyl, phenylalkyl (optionally substituted) or R5 and R6 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring; L2 represents a C1-6 alkylene chain optionally substituted by one or more C1-4 alkyl groups; and R7 and R8 independently represent hydrogen or alkyl or R7 and R8 together with the nitrogen atom to which they are attached represent a saturated 3-7 membered heterocyclic ring; are disclosed (with provisos) which are anti-inflammatory and/or anti-allergic agents and/or immunomodulants useful in treating rheumatic diseases and/or neurological damage. Compositions containing these compounds and processes to make them are also disclosed.(FR) Composés de la formule (I) ainsi que leurs sels pharmaceutiquement acceptables, dans laquelle R1, R2, R3 et R4 représentent indépendamment hydrogène, hydroxy, halo, alcoyle halogéné, alcoxy halogéné, alcoyle, alcoxy, cyano, un groupe carbamoyle de formule CONRARB, un groupe alcoxy carbonyle, ou bien R1 et R2, ensemble avec le noyau phényle, représentent un noyau naphtalène (éventuellement substitué); L1 représente alcoylène C2-6 éventuellement substitué par un ou plusieurs groupes alcoyles C1-4; R5 représente hydrogène ou alcoyle, R6 représente hydrogène ou alcoyle, phénylalcoyle (éventuellement substitué) ou bien R5 et R6, ensemble avec l'atome d'azote auquel ils sont attachés, représentent un noyau hétérocyclique saturé possédant 3 à 7 éléments; L2 représente une chaîne alcoylène C1-6 éventuellement substituée par un ou plusieurs groupes alcoyle C1-4; et R7 et R8 représentent indépendamment hydrogène ou alcoyle, ou R7 et R8, ensemble avec l'atome d'azote auquel ils sont attachés, représentent un noyau hétérocyclique saturé possédant 3 à 7 éléments. Ces composés (sous certaines conditions) constituent des agents anti-inflammatoires et/ou antiallergiques et/ou des immunomodulateurs utiles dans le traitement des maladies rhumatismales et/ou dans les lésions neurologiques. L'invention concerne également des compositions contenant ces composés ainsi que des procédés de fabrication de ceux-ci.