| 1350555-44-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• CAS: 1350555-44-0
• 化学式: C₁₅H₂₅NO
• 分子量: 235.37
• InChiKey: DZHMEIAWEANCNE-LOACHALJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.21
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  12.47
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  吗啉 、 一氧化碳 、 甜橙提取物 在 methoxy(cyclooctadiene)rhodium(I) dimer 、 氢气 、 三苯基膦 作用下， 以 甲苯 为溶剂， 100.0 ℃ 、6.08 MPa 条件下， 反应 22.0h， 生成 、 4-[3-[(1R)-4-methylcyclohex-3-en-1-yl]butyl]morpholine
  参考文献：
  名称：

  An efficient method for the transformation of naturally occurring monoterpenes into amines through rhodium-catalyzed hydroaminomethylation

  摘要：

  The hydroaminomethylation (hydroformylation/reductive amination) of the naturally occurring monoterpenes, i.e., limonene, camphene, and beta-pinene, was studied having as condensation counterparts the amines di-n-butylamine, morpholine or n-butylamine. Moderate to good yields (75-94%) were obtained employing [Rh(cod)(mu-OMe)](2) as pre-catalyst in the presence or not of triphenylphosphine or tribenzylphosphine as ancillaries in toluene, at 100 degrees C and 60 bar of an equimolar mixture of carbon monoxide and hydrogen. Some of the hydroaminomethylation products derived from limonene have biological activity and the products derived from camphene and beta-pinene are new. (C) 2011 Elsevier BM. All rights reserved.

  DOI：

  10.1016/j.apcata.2011.10.021