(2S,4R)-1-[1-(4-chloro-phenyl)-cyclopropanecarbonyl]-4-[4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-benzenesulfonyl]-pyrrolidine-2-carboxylic acid | 1439404-52-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-1-[1-(4-chloro-phenyl)-cyclopropanecarbonyl]-4-[4-(2,2,2-trifluoro-ethoxy)-2-trifluoromethyl-benzenesulfonyl]-pyrrolidine-2-carboxylic acid
• 英文别名: (2S,4R)-1-(1-(4-chlorophenyl)cyclopropanecarbonyl)-4-(4-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)phenylsulfonyl)pyrrolidine-2-carboxylic acid；(2S,4R)-1-[1-(4-chlorophenyl)cyclopropanecarbonyl]-4-[4-(2,2,2-trifluoroethoxy)-2-(trifluoromethyl)phenyl]sulfonylpyrrolidine-2-carboxylic acid
• CAS: 1439404-52-0
• 化学式: C₂₄H₂₀ClF₆NO₆S
• 分子量: 599.935
• InChiKey: XTICQRJMILXXRL-AEFFLSMTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  39
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  109
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• NOVEL PYRROLIDINE DERIVATIVES
  申请人：Hoffmann-La Roche Inc.

  公开号：US20130137687A1

  公开（公告）日：2013-05-30

  The invention relates to a compound of formula (I) wherein A and R 1 to R 7 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

  本发明涉及一种公式(I)的化合物 其中A和R 1 至R 7 定义如描述和权利要求中所述。公式(I)的化合物可作为药物使用。
• [EN] NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN<br/>[FR] NOUVEAUX DÉRIVÉS DE PYRROLIDINE COMME INHIBITEURS DES CATHEPSINES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2013076063A1

  公开（公告）日：2013-05-30

  The invention relates to a compound of formula (I), wherein A and R1 to R7 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

  本发明涉及公式(I)的化合物，其中A和R1至R7的定义如描述和权利要求中所述。公式(I)的化合物可用作药物。
• EP2782903A1
  申请人：——

  公开号：EP2782903A1

  公开（公告）日：2014-10-01
• NOVEL PYRROLIDINE DERIVATIVES AS INHIBITORS OF CATHEPSIN
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2782903B1

  公开（公告）日：2016-04-06
• OXYGENATE ADDITIVE FOR INTERNAL COMBUSTION ENGINE FUEL, FUEL COMPOSITION COMPRISING THE SAME AND IMPROVED PROCESS FOR PRODUCING HIGHLY METHYLATED GLYCEROL ETHERS
  申请人：CHANG Jyh-Shyong

  公开号：US20130133245A1

  公开（公告）日：2013-05-30

  The invention relates to an oxygenate additive for an internal combustion engine fuel, comprising glycerol dimethyl ethers (GDMEs) and glycerol trimethyl ether (GTME); a fuel composition comprising the oxygenate additive; an improved process for methylation of glycerol with dimethyl sulfate to produce highly methylated glycerol ethers; and uses of ethers produced from the process for diesel fuel, for gasoline and for aviation turbine fuel, or as a green solvent or as an antifreezer.