Atuzaginstat | 2211981-76-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: Atuzaginstat
• 英文别名: N-[(3S)-7-amino-2-oxo-1-(2,3,6-trifluorophenoxy)heptan-3-yl]cyclopentanecarboxamide
• CAS: 2211981-76-7
• 化学式: C₁₉H₂₅F₃N₂O₃
• 分子量: 386.4
• InChiKey: OLIMBXKACVCIMM-HNNXBMFYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  81.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] KETONE INHIBITORS OF LYSINE GINGIPAIN<br/>[FR] INHIBITEURS CÉTONE DE LYSINE GINGIPAÏNE
  申请人：CORTEXYME INC

  公开号：WO2018053353A1

  公开（公告）日：2018-03-22

  The present invention provides compounds according to Formula (I) as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

  本发明提供了如下式（I）所述的化合物，以及它们用于抑制牙龈假单胞菌（Porphyromonas gingivalis）的赖氨酸基因底物蛋白酶（Kgp）的用途。还描述了牙龈蛋白酶活性探针化合物和测定牙龈蛋白酶活性的方法，以及用于治疗与牙龈假单胞菌感染相关的疾病的方法，包括阿尔茨海默病等脑部疾病。
• Ketone inhibitors of lysine gingipain
  申请人：CORTEXYME, INC.

  公开号：US10730826B2

  公开（公告）日：2020-08-04

  The present invention provides compounds according to Formula I as described herein, and their use for inhibiting the lysine gingipain protease (Kgp) from the bacterium Porphyromonas gingivalis. Also described are gingipain activity probe compounds and methods for assaying gingipain activity are also described, as well as methods for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimer's disease.

  本发明提供了根据本文所述式 I 的化合物及其用于抑制牙龈卟啉单胞菌的赖氨酸gingipain蛋白酶（Kgp）的用途。本发明还描述了龈肽酶活性探针化合物和检测龈肽酶活性的方法，以及治疗与牙龈卟啉单胞菌感染有关的疾病（包括阿尔茨海默病等脑部疾病）的方法。
• KETONE INHIBITORS OF LYSINE GINGIPAIN
  申请人：Cortexyme, Inc.

  公开号：EP3512846A1

  公开（公告）日：2019-07-24