2-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]guanidine;hydrochloride | 146891-63-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]guanidine;hydrochloride
• CAS: 146891-63-6
• 化学式: C₁₁H₁₆N₄O₃*ClH
• 分子量: 288.734
• InChiKey: PUZZKUPCGPZTTM-JSSTZBRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.74
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  肼甲酰亚胺酰胺一氯化氢 、 3,4,5-三甲氧基苯甲醛 以 甲醇 、 水 为溶剂， 以80%的产率得到2-[(E)-(3,4,5-trimethoxyphenyl)methylideneamino]guanidine;hydrochloride
  参考文献：
  名称：

  On the structure of guanylhydrazones derived from aromatic aldehydes

  摘要：

  The synthesis of some novel guanylhydrazones derived from aromatic aldehydes (benzylideneaminoguanidines) is described. Structural assignments of these compounds as well as of some already known congeners, particularly with respect to the configuration of the HC = N double bond, were achieved using H-1- and C-13-NMR data as well as homonuclear NOE difference spectroscopy.

  DOI：

  10.1007/bf00808279

文献信息

• Treating neuropathic pain with neuropeptide FF receptor 2 agonists
  申请人：Scully L. Audra

  公开号：US20050136444A1

  公开（公告）日：2005-06-23

  The invention described below relates to the discovery of the neuropeptide FF receptor subtype that mediates acute nociception and chronic neuropathic pain, compounds that selectively interact with this receptor subtype and methods for treating acute pain and chronic neuropathic pain.

  以下所描述的发明涉及到发现了介导急性痛觉和慢性神经病理性疼痛的神经肽FF受体亚型、与该受体亚型有选择性相互作用的化合物以及治疗急性疼痛和慢性神经病理性疼痛的方法。
• On the structure of guanylhydrazones derived from aromatic aldehydes
  作者：Wolfgang Holzer、Zolt�n Gy�rgyde�k

  DOI：10.1007/bf00808279

  日期：1992.12

  The synthesis of some novel guanylhydrazones derived from aromatic aldehydes (benzylideneaminoguanidines) is described. Structural assignments of these compounds as well as of some already known congeners, particularly with respect to the configuration of the HC = N double bond, were achieved using H-1- and C-13-NMR data as well as homonuclear NOE difference spectroscopy.