ProOPp | 147221-39-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ProOPp
• CAS: 147221-39-4
• 化学式: C₁₄H₁₉NO₂
• 分子量: 233.31
• InChiKey: HWERDQUTNXZYLK-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.22
• 重原子数：
  17.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  ProOPp 在 哌啶 、 benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate 、 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.5h， 生成 Fmoc-Asp(OtBu)-Lys(Boc)-ProOPp
  参考文献：
  名称：

  2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments

  摘要：

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

  DOI：

  10.1016/s0040-4039(00)60578-6
• 作为产物：
  描述：

  Fmoc-L-脯氨酸 在 哌啶 作用下， 以 二氯甲烷 、 环己烷 为溶剂， 生成 ProOPp
  参考文献：
  名称：

  2-phenyl isopropyl esters as car☐yl terminus protecting groups in the fast synthesis of peptide fragments

  摘要：

  The esters of Fmoc aminoacids derived from 2-phenylisopropanol have been prepared by using 2-phenylisopropyltrichloroacetimidate 1. They prevent diketopiperazine formation during amino deprotection of dipeptides and can be cleaved in the presence of Boc and O-Bu(t). They are thus well suited for the protection of C-terminus when a Fmoc strategy is used to build up peptide fragments.

  DOI：

  10.1016/s0040-4039(00)60578-6

文献信息

• Solid-Phase Synthesis of Oxetane Modified Peptides
  作者：Jonathan D. Beadle、Astrid Knuhtsen、Alex Hoose、Piotr Raubo、Andrew G. Jamieson、Michael Shipman

  DOI：10.1021/acs.orglett.7b01466

  日期：2017.6.16

  Solid-phase peptide synthesis (SPPS) is used to create peptidomimetics in which one of the backbone amide C═O bonds is replaced by a four-membered oxetane ring. The oxetane containing dipeptide building blocks are made in three steps in solution, then integrated into peptide chains by conventional Fmoc SPPS. This methodology is used to make a range of peptides in high purity including backbone modified

  固相肽合成（SPPS）用于创建拟肽，其中主链酰胺C═O键之一被四元氧杂环丁烷环取代。含氧杂环丁烷的二肽结构单元可在溶液中分三步制备，然后通过常规的Fmoc SPPS整合到肽链中。该方法用于制备一系列高纯度的肽，包括九肽缓激肽的主链修饰衍生物以及Met-和Leu-脑啡肽。