trans-4-Aminomethylcyclohexancarboxamid | 121487-74-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: trans-4-Aminomethylcyclohexancarboxamid
• CAS: 121487-74-9
• 化学式: C₈H₁₆N₂O
• 分子量: 156.228
• InChiKey: RSILLSRLAWUTAY-LJGSYFOKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.24
• 重原子数：
  11.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  69.11
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  trans-4-(N-carbobenzyloxy)aminomethyl-1-cyclohexane carbonyl chloride 生成 trans-4-Aminomethylcyclohexancarboxamid
  参考文献：
  名称：

  抗纤溶酶药物的药物化学研究。4.反式-4-氨基甲基环己烷羧酸的化学修饰及其对抗纤溶酶活性的影响。

  摘要：

  DOI：

  10.1021/jm00273a011

文献信息

• External preparation for skin containing a depigmentation agent
  申请人：SHISEIDO COMPANY LIMITED

  公开号：EP0585130A2

  公开（公告）日：1994-03-02

  An external preparation for skin including one or more than two types of tranexamic acid derivatives represented by the following general formula (A). GENERAL FORMULA (A) (In the formula (A), R₁, R₂ and R₃ represents hydrogen atoms or substituents and at least one of these is the substituent.) The external preparation for skin including the derivatives have excellent depigmentation effect as well as skin care effect.

  一种皮肤外用制剂，包括一种或两种以上由以下通式(A)代表的氨甲环酸衍生物。 通式（A） (式(A)中，R₁、R₂和 R₃ 代表氢原子或取代基，且其中至少有一个是取代基)。包括这些衍生物在内的皮肤外用制剂具有极佳的祛斑效果和护肤效果。
• Melatonergic agents
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：EP0706994A1

  公开（公告）日：1996-04-17

  New melatonergic agents are phenyl alkanyl or phenyl alkyl substituted carboxamides and ureas of Formula I: wherein: R₁ = C₁₋₃ alkyl, allyl, C₃₋₆ cycloalkyl substituted C₁₋₄ alkyl; R₂ = hydrogen, halogen or C₁₋₄ alkoxy; R₃ = hydrogen or C₁₋₄ alkyl; R₄ = C₁₋₄ alkyl, C₁₋₄ alkyl substituted amino, carboxylic acid substituted C₁₋₄ alkyl or C₃₋₆ cycloalkyl, C₁₋₄ alkoxy substituted C₁₋₄ alkyl, C₃₋₆ cycloalkyl, or straight or branched chain C₂₋₄ alkenyl; A = a linear C₂₋₄ alkanediyl or alkenediyl chain, provided that A not be -CH₂CH₂- when X is a bond; and X = a covalent bond or oxygen.

  新的褪黑激素制剂是式 I 的苯基烷基或苯基烷基取代的羧酰胺和脲： 其中 R₁ = C₁₋₃ 烷基、烯丙基、C₃₋₆ 环烷基取代的 C₁₋₄ 烷基； R₂ = 氢、卤素或 C₁₋₄ 烷氧基； R₃ = 氢或 C₁₋₄ 烷基； R₄ = C₁₋₄ 烷基、C₁₋₄ 烷基取代的氨基、羧酸取代的 C₁₋₄ 烷基或 C₃₋₆ 环烷基、C₁₋₄ 烷氧基取代的 C₁₋₄ 烷基、C₃₋₆ 环烷基或直链或支链 C₂₋₄ 烯基； A = 直链 C₂₋₄烷二基或烯二基，但当 X 为键时，A 不得为-CH₂CH₂-；以及 X = 共价键或氧。
• WHITENING COMPOSITION CONTAINING REDUCED COENZYME Q
  申请人：Kaneka Corporation

  公开号：EP1790238A1

  公开（公告）日：2007-05-30

  The present invention provides a cosmetic or food composition which is excellent in a skincare effect, particularly an effect of whitening the skin browned due to ultraviolet radiation or aging, and which can be safely used for many mammals. The present invention provides a whitening composition comprising reduced coenzyme Q represented by formula (1) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a whitening composition further comprising oxidized coenzyme Q represented by formula (2) as an effective component: wherein n represents an integer of 1 to 12. The present invention also provides a method for whitening the skin of a mammal, the method comprising administering the mammal with the composition.

  本发明提供了一种化妆品或食品组合物，该组合物具有极佳的护肤效果，特别是美白由于紫外线辐射或老化而变色的皮肤的效果，并且可以安全地用于许多哺乳动物。本发明提供了一种美白组合物，该组合物包含由式（1）代表的还原型辅酶 Q 作为有效成分：其中 n 代表 1 至 12 的整数。本发明还提供了一种美白组合物，进一步包含由式（2）代表的氧化型辅酶 Q 作为有效成分：其中 n 代表 1 至 12 的整数。本发明还提供了一种美白哺乳动物皮肤的方法，该方法包括向哺乳动物施用该组合物。
• WATER-CONTAINING COMPOSITION
  申请人：Shiseido Company, Ltd.

  公开号：EP2308512A1

  公开（公告）日：2011-04-13

  When a poorly water-soluble UV-absorbing agent is used, difficulty is encountered in solubilization of a sufficient amount of the poorly water-soluble UV-absorbing agent by means of a surfactant such as polyoxyethylene alkyl ether or polyoxyethylene hydrogenated castor oil. An object of the present invention is to provide a water-containing composition in which a poorly water-soluble UV-absorbing agent is solubilized or dispersed in water. Another object of the invention is to stabilize a water-soluble ingredient; i.e., a water-soluble drug or a water-soluble dye, through co-presence of the water-soluble ingredient with the poorly water-soluble UV-absorbing agent dissolved in water. The present inventors have found that the aforementioned objects can be attained through provision of a water-containing composition which contains the following ingredients (1) to (3) and may contain a water-soluble drug and/or a water-soluble dye: (1) a polyoxyethylene addition compound represented by formula HO(CH2CH2O)n-R (I), wherein R represents a phytosterol residue or a phytostanol residue, and n is a number of 5 to 100, (2) a poorly water-soluble UV-absorbing agent, and (3) water.

  当使用水溶性差的紫外线吸收剂时，很难通过聚氧乙烯烷基醚或聚氧乙烯氢化蓖麻油等表面活性剂来溶解足量的水溶性差的紫外线吸收剂。本发明的一个目的是提供一种含水组合物，在该组合物中，水溶性差的紫外线吸收剂被溶解或分散在水中。本发明的另一个目的是通过水溶性成分与溶于水的水溶性差的紫外线吸收剂的共存来稳定水溶性成分，即水溶性药物或水溶性染料。本发明者发现，通过提供一种含水组合物可以达到上述目的，该组合物含有以下成分 （1）至（3），并可能含有水溶性药物和/或水溶性染料：(1) 由式 HO(CH2CH2O)n-R (I)代表的聚氧乙烯加成化合物，其中 R 代表植物甾醇残基或植物甾醇残基，n 为 5 至 100 的数字；(2) 水溶性差的紫外线吸收剂；(3) 水。
• Wrinkle ameliorating agent
  申请人：POLA CHEMICAL INDUSTRIES, INC.

  公开号：US10813859B2

  公开（公告）日：2020-10-27

  The object is to provide a wrinkle improving agent having an excellent wrinkle improving effect. A compound expressed by the following Formulas (1) and/or (2) is used as an active ingredient of a wrinkle improving agent. (In Formulas (1) and (2), R and R′ independently represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R″ represents an alkylene group having 1 to 3 carbon atoms, and n represents a number of 0 or 1.)

  本发明的目的是提供一种具有优异抗皱效果的抗皱剂。 由下列式子（1）和/或（2）表示的化合物可用作皱纹改善剂的活性成分。 在式子（1）和（2）中，R 和 R′分别代表氢原子或具有 1 至 4 个碳原子的烷基，R″代表具有 1 至 3 个碳原子的亚烷基，n 代表 0 或 1。