3’-isopropyl-4-methoxy-[1,1’]-biphenyl-2-carbaldehyde | 1408053-81-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3’-isopropyl-4-methoxy-[1,1’]-biphenyl-2-carbaldehyde
• 英文别名: 5-Methoxy-2-(3-propan-2-ylphenyl)benzaldehyde；5-methoxy-2-(3-propan-2-ylphenyl)benzaldehyde
• CAS: 1408053-81-5
• 化学式: C₁₇H₁₈O₂
• 分子量: 254.329
• InChiKey: ORLLLINHOKNQOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-碘异丙基苯 、 2-溴-5-甲氧基苄醇 在 norbornene 、 palladium diacetate 、 cesium pivalate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以91%的产率得到3’-isopropyl-4-methoxy-[1,1’]-biphenyl-2-carbaldehyde
  参考文献：
  名称：

  A Sequential Pd/Norbornene-Catalyzed Process Generates o-Biaryl Carbaldehydes or Ketones via a Redox Reaction or 6H-Dibenzopyrans by C–O Ring Closure

  摘要：

  o-Biaryl carbaldeydes and ketones are obtained through the one-pot reaction of o-aryl iodides with o-bromobenzyl alcohols under the catalytic action of Pd and norbornene, in the presence of a base. The same reaction can also give dibenzopyrans by Pd and norbornene catalysis with a different termination, leading to C-O ring closure. In both cases the process first leads to a five-membered palladacycle, which controls C-C coupling, then to a seven-membered oxapalladacycle, which gives aldehydes and ketones or dibenzopyrans.

  DOI：

  10.1021/ol302889t

文献信息

• [EN] ACYLTRYPTOPHANOLS<br/>[FR] ACYLTRYPTOPHANOLS
  申请人：SCHERING AG

  公开号：WO2007017289A2

  公开（公告）日：2007-02-15

  [EN] The present patent application relates to acyltryptophanols of the general formula I, in which Q, X, Y, W, R1, R2, R3, R4, R5, R8 have the meanings stated in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.
  [FR] L'invention concerne des acyltryptophanols représentés par la formule (I), dans laquelle Q, X, Y, W, R1, R2, R3, R4, R5, R8 ont les significations définies dans la description. Les composés de l'invention sont des antagonistes FSH efficaces et peuvent être utilisés, par exemple, pour réguler la fécondité chez les hommes ou chez les femmes ou pour prévenir et/ou traiter l'ostéoporose.
• A Sequential Pd/Norbornene-Catalyzed Process Generates <i>o-</i>Biaryl Carbaldehydes or Ketones via a Redox Reaction or 6<i>H</i>-Dibenzopyrans by C–O Ring Closure
  作者：Elena Motti、Nicola Della Ca’、Di Xu、Anna Piersimoni、Elena Bedogni、Zhi-Ming Zhou、Marta Catellani

  DOI：10.1021/ol302889t

  日期：2012.11.16

  o-Biaryl carbaldeydes and ketones are obtained through the one-pot reaction of o-aryl iodides with o-bromobenzyl alcohols under the catalytic action of Pd and norbornene, in the presence of a base. The same reaction can also give dibenzopyrans by Pd and norbornene catalysis with a different termination, leading to C-O ring closure. In both cases the process first leads to a five-membered palladacycle, which controls C-C coupling, then to a seven-membered oxapalladacycle, which gives aldehydes and ketones or dibenzopyrans.