4-(3-isopropyl-2-(1-phenylvinyl)phenyl)morpholine | 1618666-59-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-isopropyl-2-(1-phenylvinyl)phenyl)morpholine
• 英文别名: 4-[2-(1-Phenylethenyl)-3-propan-2-ylphenyl]morpholine；4-[2-(1-phenylethenyl)-3-propan-2-ylphenyl]morpholine
• CAS: 1618666-59-3
• 化学式: C₂₁H₂₅NO
• 分子量: 307.436
• InChiKey: ZRDPFUDTKPZPJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  吗啉-4-基苯甲酸酯 、 苯乙酮对甲苯磺酰腙 、 2-碘异丙基苯 在 norbornene 、 palladium diacetate 、 caesium carbonate 、 三苯基膦 作用下， 以 甲苯 为溶剂， 反应 20.25h， 生成 4-(3-isopropyl-2-(1-phenylvinyl)phenyl)morpholine
  参考文献：
  名称：

  Palladium-Catalyzed/Norbornene-Mediated ortho-Amination/N-Tosylhydrazone Insertion Reaction: An Approach to the Synthesis of ortho-Aminated Vinylarenes

  摘要：

  ortho-Aminated vinylarene derivatives were obtained via a reaction of aryl iodides, N-benzoyloxyamines, and N-tosylhydrazones. This approach involves a palladium-catalyzed, norbomene-mediated ortho-amination/N-tosylhydrazone insertion reaction. In this transformation, one C-N bond and one C-C bond are formed and an amine group is introduced at the ortho position successfully.

  DOI：

  10.1021/jo501125b

文献信息

• Palladium-Catalyzed/Norbornene-Mediated <i>ortho</i>-Amination/<i>N</i>-Tosylhydrazone Insertion Reaction: An Approach to the Synthesis of <i>ortho</i>-Aminated Vinylarenes
  作者：Ping-Xin Zhou、Yu-Ying Ye、Jun-Wei Ma、Lan Zheng、Qian Tang、Yi-Feng Qiu、Bo Song、Zi-Hang Qiu、Peng-Fei Xu、Yong-Min Liang

  DOI：10.1021/jo501125b

  日期：2014.7.18

  ortho-Aminated vinylarene derivatives were obtained via a reaction of aryl iodides, N-benzoyloxyamines, and N-tosylhydrazones. This approach involves a palladium-catalyzed, norbomene-mediated ortho-amination/N-tosylhydrazone insertion reaction. In this transformation, one C-N bond and one C-C bond are formed and an amine group is introduced at the ortho position successfully.