| 1334552-65-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 异硫氰酸盐
• CAS: 1334552-65-6
• 化学式: C₁₄H₁₅NO₃S
• 分子量: 277.344
• InChiKey: BQPVPGLNJYVXQJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.78
• 重原子数：
  19.0
• 可旋转键数：
  10.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  40.05
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  、 2-(2-Azidoethoxy)ethyl 2,3,4,6-tetra-O-acetyl-α-D-mannopyranoside 在 copper(II) sulfate 、 sodium ascorbate 、 乙二胺四乙酸 作用下， 以 四氢呋喃 、 水 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Clusters of ligands on dendrimer surfaces

  摘要：

  The development of methodology that is designed to allow a significant increase in the patterning and in the functionalization of the dendrimer is the ultimate goal of the research described here. Glycoside clusters based on TRIS were formed using click chemistry and were attached to PAMAM dendrimers. A series of dendrimers bearing tris-mannoside and an ethoxyethanol group was synthesized, and the binding interactions of these dendrimers with Concanavalin A were evaluated using inhibition ELISAs. The results of the inhibition ELISAs suggest that tris-mannoside clusters can replace individual sugars on the dendrimer without loss of function. Since tris-mannoside clustering allows for a redistribution of the dendrimers' surface functionalities, from this chemistry one can envision patterned dendrimers that incorporate multiple groups to increase the function and utility of the dendrimer. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.100
• 作为产物：
  描述：

  N-(tert-butyloxycarbonyl)tris[(propargyloxy)methyl]aminomethane 在 三氟乙酸 作用下， 生成
  参考文献：
  名称：

  Clusters of ligands on dendrimer surfaces

  摘要：

  The development of methodology that is designed to allow a significant increase in the patterning and in the functionalization of the dendrimer is the ultimate goal of the research described here. Glycoside clusters based on TRIS were formed using click chemistry and were attached to PAMAM dendrimers. A series of dendrimers bearing tris-mannoside and an ethoxyethanol group was synthesized, and the binding interactions of these dendrimers with Concanavalin A were evaluated using inhibition ELISAs. The results of the inhibition ELISAs suggest that tris-mannoside clusters can replace individual sugars on the dendrimer without loss of function. Since tris-mannoside clustering allows for a redistribution of the dendrimers' surface functionalities, from this chemistry one can envision patterned dendrimers that incorporate multiple groups to increase the function and utility of the dendrimer. (c) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.100