氟康唑杂质 | 1449785-88-9

• 物质功能分类: 分析化学 - 标准品 - 药典标准品和杂质标准品
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 氟康唑杂质
• 英文名称: 2-(2,4-difluorophenyl)-1-(1H-1,2,4,-triazol-1-yl)ethen-2-ol
• CAS: 1449785-88-9
• 化学式: C₁₀H₇F₂N₃O
• 分子量: 223.182
• InChiKey: DDLPRYJTDUIELF-UHFFFAOYSA-N

物化性质

• 沸点：
  370.0±52.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.07
• 重原子数：
  16.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  50.94
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  伏立康唑 在 sodium hydroxide 作用下， 以 甲醇-d3 为溶剂， 反应 17.0h， 生成 氟康唑杂质
  参考文献：
  名称：

  ¹H and ¹⁹F NMR in drug stress testing: the case of voriconazole

  摘要：

  应力测试是药物开发和后续认证的重要组成部分。

  DOI：

  10.1039/c7ra03822d

文献信息

• NOVEL SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF FLUCONAZOLE IN THE PRESENCE OF ITS OXIDATIVE DEGRADATION PRODUCT
  作者：HAYAMMAHMOUD LOTFY、HANY HUNTER MONIR、ABD EL-AZIZEL-BAYOUMI ABD EL-ALEEM

  DOI：10.4067/s0717-97072012000400023

  日期：——

  Five sensitive, selective and precise spectrophotometric stability-indicating methods for the determination of fluconazole in the presence of its oxidative degradation product and in pharmaceutical formulations are developed and validated. Method A is a newly developed spectrophotometric one that is called ratio difference method by measuring the difference in amplitudes between 261.5 and 266.5 nm of ratio spectrum. Method B is a third derivative spectrophotometric one, which determines peak amplitudes from 265.5-268nm (peak-peak). Method C is ratio subtraction method. Method D is the first derivative of the ratio spectra by measuring the peak amplitude at 269 nm. Finally, method E is the mean centering of ratio spectra method by measuring the peak amplitude at 266.5 nm. The proposed methods allow the determination of fluconazole in the presence of its oxidative degradation product over a concentration range of 50-400 mu g.mL(-1) with mean percentage recoveries of 100.24 +/- 0.91, 99.91 +/- 0.52, 100.20 +/- 1.26, 99.79 +/- 0.69, and 100.77 +/- 0.72 respectively.The selectivity of the proposed methods is checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of fluconazole in pharmaceutical dosage forms without interference from other dosage form additives and the results have been statistically compared with a reported method.