3,3'-diphenyl-1,1'-pyridine-2,6-diyl-bis-thiourea | 25759-71-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,3'-diphenyl-1,1'-pyridine-2,6-diyl-bis-thiourea
• 英文别名: 1-Phenyl-3-[6-(phenylcarbamothioylamino)pyridin-2-yl]thiourea
• CAS: 25759-71-1
• 化学式: C₁₉H₁₇N₅S₂
• 分子量: 379.509
• InChiKey: PINBYAQEDIXCKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  125
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,6-二氨基吡啶 、 硫代异氰酸苯酯 以 四氢呋喃 为溶剂， 40.0 ℃ 、600.0 MPa 条件下， 反应 44.0h， 以75%的产率得到3,3'-diphenyl-1,1'-pyridine-2,6-diyl-bis-thiourea
  参考文献：
  名称：

  High-pressure-promoted condensation of isothiocyanates with aminopyridines: efficient synthesis of pyridine–thiourea conjugates as building blocks for hydrogen-bonding receptors

  摘要：

  New N-pyridinothiourea derivatives have been prepared by the high-pressure-promoted condensation of isothiocyanates with aminopyridines under uncatalyzed conditions. Complexation of the prototype 3c with diphenyl hydrogen phosphate was investigated by H-1 NMR, and the results suggest that it may be useful as a building block for hydrogen-bonding receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02295-x

文献信息

• High-pressure-promoted condensation of isothiocyanates with aminopyridines: efficient synthesis of pyridine–thiourea conjugates as building blocks for hydrogen-bonding receptors
  作者：Koji Kumamoto、Yoshihiro Misawa、Sumio Tokita、Yuji Kubo、Hiyoshizo Kotsuki

  DOI：10.1016/s0040-4039(01)02295-x

  日期：2002.2

  New N-pyridinothiourea derivatives have been prepared by the high-pressure-promoted condensation of isothiocyanates with aminopyridines under uncatalyzed conditions. Complexation of the prototype 3c with diphenyl hydrogen phosphate was investigated by H-1 NMR, and the results suggest that it may be useful as a building block for hydrogen-bonding receptors. (C) 2002 Elsevier Science Ltd. All rights reserved.