5-nitro-3-[(2-oxo-5-(4-methoxyphenyl)furan-3(2H)-ylidine)]indolin-2-one | 1447721-78-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-nitro-3-[(2-oxo-5-(4-methoxyphenyl)furan-3(2H)-ylidine)]indolin-2-one
• CAS: 1447721-78-9
• 化学式: C₁₉H₁₂N₂O₆
• 分子量: 364.314
• InChiKey: ZKURHLAHFGWGHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.91
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  107.77
• 氢给体数：
  1.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  5-nitro-3-[(2-oxo-5-(4-methoxyphenyl)furan-3(2H)-ylidine)]indolin-2-one 、 4-(2-氨乙基)苯磺酰胺 在 sodium acetate 、 溶剂黄146 作用下， 反应 0.05h， 以70%的产率得到4-[(2-(3-(5-nitro-2-oxoindolin-3-ylidene)-5-(4-methoxyphenyl)-2-oxo-2,3-dihydropyrrol-1-yl)ethyl)]benzenesulfonamide
  参考文献：
  名称：

  Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

  摘要：

  New furanone derivatives incorporating the indolin-2-one moiety 3 were prepared via the Perkin reaction of isatins 1 with aroylpropionic acids 2 under conventional conditions or microwave irradiation. A series of functionally heterocyclic derivatives (e.g., pyridazines, pyrroles, and sulfonamides) incorporating the indolin-2-one moiety was achieved via reaction of 3 with different reagents under microwave irradiation conditions. The newly synthesized compounds were characterized on the basis of FTIR, H-1, C-13 NMR and mass spectral studies. Some of the new synthesized compounds were screened for antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus), Gram-negative bacteria (Escherichia coli and Shigilla flexneri) and antifungal activity against Aspergillus flavus and Candida albicans. Compound 8 j was equipotent to chloramphenicol in inhibiting the growth of E. coli minimum inhibitory concentration (MIC 2.5 mu g/mL). Compound 8j may possibly be used as a lead compound for developing a new antibacterial agents. The antibacterial activity is expressed as the corresponding MIC (mu g/mL) values.

  DOI：

  10.3109/14756366.2012.689298
• 作为产物：
  描述：

  1-acetyl-5-nitro-3-[(2-oxo-5-p-methoxyphenylfuran-3(2H)-ylidine)]indolin-2-one 在 盐酸 作用下， 以 水 为溶剂， 生成 5-nitro-3-[(2-oxo-5-(4-methoxyphenyl)furan-3(2H)-ylidine)]indolin-2-one
  参考文献：
  名称：

  Synthesis of a new class of antimicrobial agents incorporating the indolin-2-one moiety

  摘要：

  New furanone derivatives incorporating the indolin-2-one moiety 3 were prepared via the Perkin reaction of isatins 1 with aroylpropionic acids 2 under conventional conditions or microwave irradiation. A series of functionally heterocyclic derivatives (e.g., pyridazines, pyrroles, and sulfonamides) incorporating the indolin-2-one moiety was achieved via reaction of 3 with different reagents under microwave irradiation conditions. The newly synthesized compounds were characterized on the basis of FTIR, H-1, C-13 NMR and mass spectral studies. Some of the new synthesized compounds were screened for antibacterial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus), Gram-negative bacteria (Escherichia coli and Shigilla flexneri) and antifungal activity against Aspergillus flavus and Candida albicans. Compound 8 j was equipotent to chloramphenicol in inhibiting the growth of E. coli minimum inhibitory concentration (MIC 2.5 mu g/mL). Compound 8j may possibly be used as a lead compound for developing a new antibacterial agents. The antibacterial activity is expressed as the corresponding MIC (mu g/mL) values.

  DOI：

  10.3109/14756366.2012.689298