[4-(3-Chloro-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone | 385436-91-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [4-(3-Chloro-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone
• 英文别名: [4-(3-Chloro-1-phenylpropoxy)phenyl]-(4-methylphenyl)methanone
• CAS: 385436-91-9
• 化学式: C₂₃H₂₁ClO₂
• 分子量: 364.872
• InChiKey: APNSINDIRQTZMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  [4-(3-Chloro-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone 在 lithium hydroxide 作用下， 生成 (Methyl-{3-[4-(4-methyl-benzoyl)-phenoxy]-3-phenyl-propyl}-amino)-acetic Acid
  参考文献：
  名称：

  [3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter

  摘要：

  The synthesis of NPTS, 6, a potent inhibitor of the type I glycine transporter (GlyT1) is described, as well as preparation of 6 in optically active and tritiated form for use as a radioligand for affinity displacement assay of GlyT1. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00126-4
• 作为产物：
  描述：

  3-氯-1-苯基丙醇 在 lithium hydroxide 、 磺酰氯 、 RO₂C-N=N-CO₂R 、 钯 、 三苯基膦 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 [4-(3-Chloro-1-phenyl-propoxy)-phenyl]-p-tolyl-methanone
  参考文献：
  名称：

  [3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter

  摘要：

  The synthesis of NPTS, 6, a potent inhibitor of the type I glycine transporter (GlyT1) is described, as well as preparation of 6 in optically active and tritiated form for use as a radioligand for affinity displacement assay of GlyT1. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00126-4

文献信息

• Benzophenones and sulfones as inhibitors of glycine uptake
  申请人：Pfizer Inc.

  公开号：US20020052401A1

  公开（公告）日：2002-05-02

  This invention relates to a series of substituted benzophenone and sulfone compounds of the formula I 1 wherein ring A, Z, Y, R and X are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.

  这项发明涉及一系列符合以下式I的取代苯并酮和砜化合物： 其中环A、Z、Y、R和X的定义如规范中所述，这些化合物表现出作为甘氨酸转运抑制剂的活性，它们的药学上可接受的盐，含有它们的药物组合物，以及它们用于增强认知和治疗哺乳动物，包括人类，的精神分裂症和其他精神病阳性和阴性症状的用途。
• Difluoromethylene aromatic ethers as inhibitors of glycine transport
  申请人：Pfizer Inc.

  公开号：US20030045569A1

  公开（公告）日：2003-03-06

  This invention relates to a series of difluoromethylene aromatic ethers of the formula 1 wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.

  这项发明涉及一系列二氟甲亚烷芳基醚化合物，其化学式如下所示：其中环A以及X和Y的定义如规范中所述，这些化合物表现出作为甘氨酸转运抑制剂的活性，它们的药学上可接受的盐，含有它们的药物组合物，以及它们用于增强认知和治疗哺乳动物，包括人类，的精神分裂症和其他精神病阳性和阴性症状的用途。
• Difluoromethylene aromatic ethers and their use as inhibitors of the glycine type-1 transporter
  申请人：Pfizer Products Inc.

  公开号：EP1284257A2

  公开（公告）日：2003-02-19

  This invention relates to a series of difluoromethylene aromatic ethers of the formula wherein ring A and X and Y are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other central nervous system disorders in mammals, including humans.

  本发明涉及一系列二氟亚甲基芳香族醚，其式为 其中环 A 以及 X 和 Y 的定义如说明书中所述，它们具有作为甘氨酸转运抑制剂的活性、它们的药学上可接受的盐、含有它们的药物组合物，以及它们用于增强哺乳动物（包括人类）的认知能力和治疗精神分裂症及其他中枢神经系统疾病的阳性和阴性症状的用途。
• BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE
  申请人：Pfizer Products Inc.

  公开号：EP1294677A1

  公开（公告）日：2003-03-26
• US6506780B2
  申请人：——

  公开号：US6506780B2

  公开（公告）日：2003-01-14