4-Dodecyl-6-(3-hydroxy-propyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester | 150252-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Dodecyl-6-(3-hydroxy-propyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
• CAS: 150252-65-6
• 化学式: C₂₁H₃₈N₂O₄
• 分子量: 382.544
• InChiKey: SDMOTTUWMNMWQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  503.6±50.0 °C(predicted)
• 密度：
  1.017±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.18
• 重原子数：
  27.0
• 可旋转键数：
  15.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  87.66
• 氢给体数：
  3.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-Dodecyl-6-(3-hydroxy-propyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester 在 盐酸 作用下， 以 甲醇 为溶剂， 生成 (5S,9S,10R)-9-Dodecyl-7-oxo-1-oxa-6,8-diaza-spiro[4.5]decane-10-carboxylic acid methyl ester 、 (5S,9R,10R)-9-Dodecyl-7-oxo-1-oxa-6,8-diaza-spiro[4.5]decane-10-carboxylic acid methyl ester 、 (5R,9R,10R)-9-Dodecyl-7-oxo-1-oxa-6,8-diaza-spiro[4.5]decane-10-carboxylic acid methyl ester 、 (5R,9S,10R)-9-Dodecyl-7-oxo-1-oxa-6,8-diaza-spiro[4.5]decane-10-carboxylic acid methyl ester
  参考文献：
  名称：

  Biomimetic synthesis of (.+-.)-crambines A, B, C1, and C2. Revision of the structure of crambines B and C1

  摘要：

  Crambines A (7) (eight steps, 22%), B (45d) (eight Steps, 19%), C1 (9d) (seven steps, 21%), and C2 (9a) (seven steps, 27%) have been synthesized expediently and stereospecifically by a biomimetic route from methyl acetoacetate. Aminodihydropyrimidines 39 and 40 are formed efficiently from enone ester 36 by a two-step procedure involving addition of O-methylisourea to give methoxydihydropyrimidine 37 followed by displacement of the methoxy group of 37 with ammonia. Hydrogenolysis of 40a and 40d afford crambines C2 and C1, respectively. Mesylation of the alcohol of 39a or 40a followed by Et3N-catalyzed cyclization and hydrogenolysis affords crambine A (7). Aminal formation from 39d or 40d in CHCl3 followed by hydrogenolysis proceeds stereospecifically to provide crambine B (45d). The structure of crambine B has been revised to the stereochemistry shown in 45 and both crambines B and Cl have a seven rather than five-carbon guanidino alkyl chain.

  DOI：

  10.1021/jo00067a014
• 作为产物：
  描述：

  methyl 6-<3-<(tert-butyldimethylsilyl)oxy>propyl>-4-dodecyl-1,4-dihydro-2-methoxypyrimidine-5-carboxylate 在 2-甲基苯磺酸 四丁基氟化铵 、 水 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 28.0h， 生成 4-Dodecyl-6-(3-hydroxy-propyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid methyl ester
  参考文献：
  名称：

  Biomimetic synthesis of (.+-.)-crambines A, B, C1, and C2. Revision of the structure of crambines B and C1

  摘要：

  Crambines A (7) (eight steps, 22%), B (45d) (eight Steps, 19%), C1 (9d) (seven steps, 21%), and C2 (9a) (seven steps, 27%) have been synthesized expediently and stereospecifically by a biomimetic route from methyl acetoacetate. Aminodihydropyrimidines 39 and 40 are formed efficiently from enone ester 36 by a two-step procedure involving addition of O-methylisourea to give methoxydihydropyrimidine 37 followed by displacement of the methoxy group of 37 with ammonia. Hydrogenolysis of 40a and 40d afford crambines C2 and C1, respectively. Mesylation of the alcohol of 39a or 40a followed by Et3N-catalyzed cyclization and hydrogenolysis affords crambine A (7). Aminal formation from 39d or 40d in CHCl3 followed by hydrogenolysis proceeds stereospecifically to provide crambine B (45d). The structure of crambine B has been revised to the stereochemistry shown in 45 and both crambines B and Cl have a seven rather than five-carbon guanidino alkyl chain.

  DOI：

  10.1021/jo00067a014

文献信息

• Biomimetic synthesis of the bicyclic guanidine moieties of crambines A and B
  作者：Barry B. Snider、Zhongping Shi

  DOI：10.1021/jo00035a005

  日期：1992.4

  The acyl portions of crambine A (six steps, 29% overall yield) and crambine B (six steps, 26% overall yield) have been efficiently and stereospecifically synthesized from methyl acetoacetate.