4-(6-bromo-2-oxo-2H-chromene-3-carbonyl)-morpholine | 38485-76-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 4-(6-bromo-2-oxo-2H-chromene-3-carbonyl)-morpholine
• 英文别名: 6-Bromcumarin-3-carbonsaeuremorpholid；6-bromo-3-(morpholin-4-ylcarbonyl)-2H-chromen-2-one；6-bromo-3-(morpholine-4-carbonyl)chromen-2-one
• CAS: 38485-76-6
• 化学式: C₁₄H₁₂BrNO₄
• mdl: MFCD00187702
• 分子量: 338.158
• InChiKey: CVLFPEPZXXJMQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(6-bromo-2-oxo-2H-chromene-3-carbonyl)-morpholine 、 2,2-dibromo-1-phenylpropan-1-one 在 锌 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 反应 0.67h， 以61%的产率得到1-benzoyl-6-bromo-1-methyl-1a-morpholinocarbonyl-1a,7b-dihydrocyclopropa[c]chromen-2-one
  参考文献：
  名称：

  Reactions of zinc enolates derived from 1-aryl-2,2-di-bromoalkanones with 2-acyl-3H-benzo[f]chromen-3-ones, 6-bromo-2-oxochromene-3-carboxamides, and 3-oxo-3H-benzo-[f]chromene-2-carboxamides

  摘要：

  由取代的1-芳基-2,2-二溴烷酮衍生的锌醇盐与2-酰基-3H-苯并[f]色烯-3-酮反应，生成1-烷基-1-酰基-1a-酰基-1a, 9c-二氢-1H-3-氧杂环丙烷[c]菲-2-酮，以单一立体异构体的形式形成。相同的锌醇盐与6-溴-2-氧-色烯-3-氨基酸酯（哌啶类和吗啉类）反应，得到1-酰基-6-溴-1-烷基-1a-哌啶（吗啉）羰基-1a, 7b-二氢环丙烷[c]色烯-2-酮，具有高立体选择性。同样，1-苯甲酰-1-甲基-1a-吗啉羰基-1a, 9c-二氢-1H-3-氧杂环丙烷[c]菲-2-酮是通过与3-氧-3H-苯并[f]色烯-2-羧酸吗啉的反应获得的。

  DOI：

  10.1007/s11178-005-0019-z

文献信息

• Image making medium
  申请人：——

  公开号：US20030035917A1

  公开（公告）日：2003-02-20

  The invention relates to an image support medium for creation of an aesthetic image that is an work or object for display. This support medium includes a polymer in an amount sufficient to enable the image to have at least one aesthetic element. In different embodiments, the image support medium is an image support stabilizer, the polymer is a synthetic absorbent or conductive polymer, or the polymer is a transparent or synthetic translucent polymer and a property of this transparent or translucent polymer is enhanced to facilitate the creation or preservation of the image by at least one stabilizer. The invention also relates to a method for preparing this image support medium. The method includes forming a reaction mixture comprising a monomer in an amount sufficient to provide or enable the image to have an aesthetic element, and processing the reaction mixture into a 2- or 3-dimensional shape.

  本发明涉及一种图像支持介质，用于创建作为作品或展示对象的美学图像。这种支撑介质包括一种聚合物，其用量足以使图像具有至少一种审美元素。在不同的实施例中，图像支持介质是一种图像支持稳定剂，聚合物是一种合成的吸收性或导电性聚合物，或者聚合物是一种透明或合成的半透明聚合物，并且这种透明或半透明聚合物的特性被至少一种稳定剂增强，以促进图像的创建或保存。本发明还涉及一种制备这种图像支持介质的方法。该方法包括形成由单体组成的反应混合物，其用量足以提供或使图像具有美学元素，并将反应混合物加工成 2 维或 3 维形状。
• Reaction of N-substituted 2-oxochromen-3-carboxamides with bromoderivatives of zinc enolates prepared from alkyl 2,2-dialkyl-4,4-dibromo-3-oxoalkanoates and zinc
  作者：V. V. Shchepin、P. S. Silaichev、N. Yu. Russkikh、M. I. Vakhrin、M. I. Kodess

  DOI：10.1134/s1070428006080094

  日期：2006.8

  Zinc enolates obtained from ethyl 2,2-dialkyl-4,4-dibromo-3-oxobutanoates and zinc react with N-substituted 2-oxochromen-3-carboxamides forming ethyl 3-1a-(R(3)-carbamoyl)-2-oxo-1a,7b-dihydrocyclopropa[c]chromen-1-yl}-2,2-dialkyl-3-oxopropanoate isomer with a Z-position of methine hydrogens. Zinc enolates prepared from alkyl 2,2-dialkyl-4,4-dibromo-3-oxopentanoates and -hexanoates and zinc react with N-substituted 2-oxochromen-3-carboxamides to give rise to esters of 3-1-alkyl-1a-(R(3)-carbamoyl)-2-oxo-1a,7b-dihydrocyclopropa[c]chromen-1-yl}-2,2-dialkyl-3-oxopropanoic acid as isomers with the E-position of the methine proton and the alkyl substituent. The reaction carried out in the presence of small quantities of THF and HMPA leads to the formation of 9c-alkyl-2-R(3)-9b,9c-dihydro-5-oxa-2-azacyclopenta[2,3]-cyclopropa[1,2-a]naphthalene-1,3,4-triones. Zinc enolates from alkyl 2,2-dialkyl-4,4-dibromo-3-oxopentanoates and -hexanoates and zinc with the secondary amides of 2-oxochromen-3-carboxylic acid form alkyl 3-2-oxo-1a-(piperidinocarbonyl)- and 3-6-R(1)-1a-(morpholinocarbonyl)-2-oxo-1a,7b-dihydrocyclopropa[c]chromen-1-yl)-2,2-R(2),R(2)-3-oxopropanoates as single geometrical isomers.
• US7629400B2
  申请人：——

  公开号：US7629400B2

  公开（公告）日：2009-12-08
• Reactions of zinc enolates derived from 1-aryl-2,2-di-bromoalkanones with 2-acyl-3H-benzo[f]chromen-3-ones, 6-bromo-2-oxochromene-3-carboxamides, and 3-oxo-3H-benzo-[f]chromene-2-carboxamides
  作者：V. V. Shchepin、M. M. Kalyuzhnyi、P. S. Silaichev、N. Yu. Russkikh、R. V. Shchepin、M. A. Ezhikova、M. I. Kodess

  DOI：10.1007/s11178-005-0019-z

  日期：2004.9

  Zinc enolates derived from substituted 1-aryl-2,2-dibromoalkanones reacted with 2-acyl-3H-benzo-[f]chromen-3-ones to give 1-alkyl-1-aroyl-1a-acyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-ones which were formed as a single stereoisomer. Reactions of the same zinc enolates with 6-bromo-2-oxo-chromene-3-carboxamides (piperidides and morpholides) afforded 1-aroyl-6-bromo-1-alkyl-1a-piperidino-(morpholino)carbonyl-1a,7b-dihydrocyclopropa[c]chromen-2-ones with high stereoselectivity. Likewise, 1-benzoyl-1-methyl-1a-morpholinocarbonyl-1a, 9c-dihydro-1H-3-oxacyclopropa[c]phenanthren-2-one was obtained by reac-tion with 3-oxo-3H-benzo[f]chromene-2-carboxylic acid morpholide.

  由取代的1-芳基-2,2-二溴烷酮衍生的锌醇盐与2-酰基-3H-苯并[f]色烯-3-酮反应，生成1-烷基-1-酰基-1a-酰基-1a, 9c-二氢-1H-3-氧杂环丙烷[c]菲-2-酮，以单一立体异构体的形式形成。相同的锌醇盐与6-溴-2-氧-色烯-3-氨基酸酯（哌啶类和吗啉类）反应，得到1-酰基-6-溴-1-烷基-1a-哌啶（吗啉）羰基-1a, 7b-二氢环丙烷[c]色烯-2-酮，具有高立体选择性。同样，1-苯甲酰-1-甲基-1a-吗啉羰基-1a, 9c-二氢-1H-3-氧杂环丙烷[c]菲-2-酮是通过与3-氧-3H-苯并[f]色烯-2-羧酸吗啉的反应获得的。