1-(3-methoxyphenyl)-7-phenyl-(4E)-hepten-3-one | 952315-96-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-(3-methoxyphenyl)-7-phenyl-(4E)-hepten-3-one
• 英文别名: (E)-1-(3-methoxyphenyl)-7-phenylhept-4-en-3-one
• CAS: 952315-96-7
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: JPJKVUGEZIHEGS-WUXMJOGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-methoxyphenyl)-7-phenyl-(4E)-hepten-3-one 在 sodium hydroxide 、 苄基三乙基氯化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 21.7h， 生成
  参考文献：
  名称：

  Interrupted Nazarov Reactions Using Dichlorocyclopropanes:  A Novel Mode of Arene Trapping

  摘要：

  2-Siloxy-2-alkenyl-1,1-dichlorocyclopropanes with aryl-terminated side chains undergo silver-assisted electrocyclic opening/Nazarov cyclization. The resulting 2-siloxycyclopentenyl cations are intercepted by the pendant arenes to furnish tricyclic adducts in moderate to good yields. In cases where the arene trap was tethered through the cyclopropane unit, a new mode of trapping occurred to generate unique bridged carbon frameworks.

  DOI：

  10.1021/ol7015669
• 作为产物：
  描述：

  苯丙醛 、 dimethyl 4-(3-methoxyphenyl)-2-oxobutylphosphonate 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.67h， 生成 1-(3-methoxyphenyl)-7-phenyl-(4E)-hepten-3-one
  参考文献：
  名称：

  Interrupted Nazarov Reactions Using Dichlorocyclopropanes:  A Novel Mode of Arene Trapping

  摘要：

  2-Siloxy-2-alkenyl-1,1-dichlorocyclopropanes with aryl-terminated side chains undergo silver-assisted electrocyclic opening/Nazarov cyclization. The resulting 2-siloxycyclopentenyl cations are intercepted by the pendant arenes to furnish tricyclic adducts in moderate to good yields. In cases where the arene trap was tethered through the cyclopropane unit, a new mode of trapping occurred to generate unique bridged carbon frameworks.

  DOI：

  10.1021/ol7015669

文献信息

• Interrupted Nazarov Reactions Using Dichlorocyclopropanes:  A Novel Mode of Arene Trapping
  作者：Tina N. Grant、F. G. West

  DOI：10.1021/ol7015669

  日期：2007.9.1

  2-Siloxy-2-alkenyl-1,1-dichlorocyclopropanes with aryl-terminated side chains undergo silver-assisted electrocyclic opening/Nazarov cyclization. The resulting 2-siloxycyclopentenyl cations are intercepted by the pendant arenes to furnish tricyclic adducts in moderate to good yields. In cases where the arene trap was tethered through the cyclopropane unit, a new mode of trapping occurred to generate unique bridged carbon frameworks.