N4-(2,2-dimethyl-3-oxo-4H-benz[1,4]oxazin-6-yl)-5-fluoro-N2-(2-trifluoromethyl-1H-benzimidazol-5-yl)-2,4-pyrimidinediamine | 841290-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: N4-(2,2-dimethyl-3-oxo-4H-benz[1,4]oxazin-6-yl)-5-fluoro-N2-(2-trifluoromethyl-1H-benzimidazol-5-yl)-2,4-pyrimidinediamine
• 英文别名: 6-[[5-fluoro-2-[[2-(trifluoromethyl)-3H-benzimidazol-5-yl]amino]pyrimidin-4-yl]amino]-2,2-dimethyl-4H-1,4-benzoxazin-3-one
• CAS: 841290-55-9
• 化学式: C₂₂H₁₇F₄N₇O₂
• 分子量: 487.416
• InChiKey: XCVWIPQHWITTKL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• FORMULATION OF INSOLUBLE SMALL MOLECULE THERAPEUTICS IN LIPID-BASED CARRIERS
  申请人：Parmar Manjeet M.

  公开号：US20090291129A1

  公开（公告）日：2009-11-26

  The present invention provides formulations containing at least one unsaturated amphiphilic lipid and an amphipathic or hydrophobic drug and methods of making these formulations. In particular, the present invention provides formulations of at least one unsaturated phospholipid and an amphipathic or hydrophobic pyrimidine drug, methods of making these formulations and the use of such formulations in a variety of contexts, including, for example, the treatment of proliferative disorders, such as tumors and cancers.
• US8246984B2
  申请人：——

  公开号：US8246984B2

  公开（公告）日：2012-08-21
• [EN] FORMULATION OF INSOLUBLE SMALL MOLECULE THERAPEUTICS IN LIPID-BASED CARRIERS<br/>[FR] FORMULATION D'AGENTS THÉRAPEUTIQUES À BASE DE PETITES MOLÉCULES INSOLUBLES DANS DES SUPPORTS LIPIDIQUES
  申请人：RIGEL PHARMACEUTICALS INC

  公开号：WO2007111720A2

  公开（公告）日：2007-10-04

  (EN) The present invention provides formulations containing at least one unsaturated amphiphilic lipid and an amphipathic or hydrophobic drug and methods of making these formulations. In particular, the present invention provides formulations of at least one unsaturated phospholipid and an amphipathic or hydrophobic pyrimidine drug, methods of making these formulations and the use of such formulations in a variety of contexts, including, for example, the treatment of proliferative disorders, such as tumors and cancers.(FR) La présente invention concerne des formulations contenant au moins un lipide amphiphile insaturé et un médicament amphipathique ou hydrophobe ainsi que des procédés de fabrication de ces formulations. En particulier, la présente invention concerne des formulations d'au moins un phospholipide insaturé et un médicament à base de pyrimidine amphipathique ou hydrophobe, des procédés de fabrication de ces formulations et l'utilisation de telles formulations dans divers contextes, comprenant, par exemple, le traitement de troubles proliférants, tels que des tumeurs et des cancers.