4-异丙基环己基甲磺酸酯 | 175020-81-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 中文名称: 4-异丙基环己基甲磺酸酯
• 英文名称: 4-isopropylcyclohexyl mesylate
• CAS: 175020-81-2
• 化学式: C₁₀H₂₀O₃S
• 分子量: 220.333
• InChiKey: OVGKOWMNJYALJP-MGCOHNPYSA-N

物化性质

• 沸点：
  330.8±9.0 °C(Predicted)
• 密度：
  1.08±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.18
• 重原子数：
  14.0
• 可旋转键数：
  3.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-异丙基环己基甲磺酸酯 在 乙醇 作用下， 以86%的产率得到4-Isopropyl-cyclohexen
  参考文献：
  名称：

  The Interaction of π Orbitals with a Carbocation over Three σ Bonds

  摘要：

  The semi-pi analogue of double hyperconjugation (''hyperconjugation/conjugation'') has been examined in 4-isopropylidenecyclohexyl mesylate (4-OMs) by comparison with the saturated analogue, trans-4-isopropylcyclohexyl mesylate(5-OMs). The unsaturated substrate reacts in 97% trifluoroethanol only four times faster than the saturated substrate. Raber-Harris plots indicate that both substrates react by k(s) mechanisms; i.e., solvolysis occurs with solvent assistance rather than carbocation formation. These results are consistent with the absence of a direct, through-bond interaction of the double bond with the reactive center. The absence is caused at least in part by less than ideal overlap of the gamma, delta pi orbitals with the alpha,beta sigma orbitals. In contrast, an electron-rich tin atom attached to the 4-position provides a large rate enhancement and changes the mechanism to carbocation formation through double hyperconjugation.

  DOI：

  10.1021/jo951643d
• 作为产物：
  描述：

  toluene-4-sulfonic acid-(trans-4-isopropyl-cyclohexyl ester) 在 吡啶 、 氢氧化钾 作用下， 以 甲醇 、 水 为溶剂， 反应 3.0h， 生成 4-异丙基环己基甲磺酸酯
  参考文献：
  名称：

  The Interaction of π Orbitals with a Carbocation over Three σ Bonds

  摘要：

  The semi-pi analogue of double hyperconjugation (''hyperconjugation/conjugation'') has been examined in 4-isopropylidenecyclohexyl mesylate (4-OMs) by comparison with the saturated analogue, trans-4-isopropylcyclohexyl mesylate(5-OMs). The unsaturated substrate reacts in 97% trifluoroethanol only four times faster than the saturated substrate. Raber-Harris plots indicate that both substrates react by k(s) mechanisms; i.e., solvolysis occurs with solvent assistance rather than carbocation formation. These results are consistent with the absence of a direct, through-bond interaction of the double bond with the reactive center. The absence is caused at least in part by less than ideal overlap of the gamma, delta pi orbitals with the alpha,beta sigma orbitals. In contrast, an electron-rich tin atom attached to the 4-position provides a large rate enhancement and changes the mechanism to carbocation formation through double hyperconjugation.

  DOI：

  10.1021/jo951643d

文献信息

• COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS
  申请人：BIOGEN IDEC MA INC.

  公开号：US20150203515A1

  公开（公告）日：2015-07-23

  Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).

  式(I)的化合物可以调节一个或多个SIP受体的活性和/或自体向素（ATX）的活性。
• US9550798B2
  申请人：——

  公开号：US9550798B2

  公开（公告）日：2017-01-24
• US9944666B2
  申请人：——

  公开号：US9944666B2

  公开（公告）日：2018-04-17
• [EN] COMPOUNDS THAT ARE S1P MODULATING AGENTS AND/OR ATX MODULATING AGENTS<br/>[FR] COMPOSÉS ÉTANT DES AGENTS DE MODULATION DE S1P ET/OU DES AGENTS DE MODULATION D'ATX
  申请人：BIOGEN IDEC INC

  公开号：WO2014018891A1

  公开（公告）日：2014-01-30

  Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).