4-(E-Pent-1-enyl)-1,2-dimethoxy benzene | 77821-96-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(E-Pent-1-enyl)-1,2-dimethoxy benzene
• 英文别名: 1,2-dimethoxy-4-[(E)-pent-1-enyl]benzene
• CAS: 77821-96-6
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: CHXGKXZGBGTGDR-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.52
• 重原子数：
  15.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  4-(E-Pent-1-enyl)-1,2-dimethoxy benzene 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 生成 (5,6-Dimethoxy-2-propyl-1H-inden-1-yl)-dimethyl-amine
  参考文献：
  名称：

  Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist

  摘要：

  Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene calcium antagonists reversed the spasmogenic action of several agonists including PGF2alpha and acetylcholine at 5 X 10(-5) to 10(-4) M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10(-4)-10(-3) M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10(-6)-10(-5) M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10(-4) M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10(-3) M all four analogues were capable of moderately antagonizing the actions of acetylcholine.

  DOI：

  10.1021/jm00210a028
• 作为产物：
  描述：

  3,4-二甲氧基苯甲醛 在 对甲苯磺酸 作用下， 以 乙醚 、 正己烷 、 苯 为溶剂， 生成 4-(E-Pent-1-enyl)-1,2-dimethoxy benzene
  参考文献：
  名称：

  Pharmacology on rat ileum of certain 2-substituted 3-(dimethylamino)-5,6-dimethoxyindenes related to 5,6-(methylendioxy)indene calcium antagonist

  摘要：

  Whereas the 2-propyl- and 2-butyl-5,6-(methylenedioxy)indene calcium antagonists reversed the spasmogenic action of several agonists including PGF2alpha and acetylcholine at 5 X 10(-5) to 10(-4) M on the rat ileum, the corresponding 5,6-dimethoxy analogues exhibited spasmogenic activity at higher concentration (10(-4)-10(-3) M) and exhibited neither spasmogenic nor spasmolytic activity at lower (10(-6)-10(-5) M) concentration. The results are compared to the methyl and 2-ethyl analogues. At 10(-4) M only the butyl analogue was capable of moderate antagonism of acetylcholine and at 10(-3) M all four analogues were capable of moderately antagonizing the actions of acetylcholine.

  DOI：

  10.1021/jm00210a028

文献信息

• Neutral Ionic Liquid [hmim]Br as a Green Reagent and Solvent for the Mild and Efficient Dehydration of Benzyl Alcohols into (<i>E</i>)-Arylalkenes Under Microwave Irradiation
  作者：Rakesh Kumar、Abhishek Sharma、Naina Sharma、Vinod Kumar、Arun K. Sinha

  DOI：10.1002/ejoc.200800657

  日期：2008.11

  A mild and efficient, ionic-liquid-assisted, green protocol for the dehydration of benzyl alcohols into the corresponding (E)-arylalkenes under microwave irradiation has been developed. The method utilizes a neutral and recyclable ionic liquid (1-hexyl-3-methylimidazolium bromide) as a reagent and solvent to cleanly provide a wide range of olefins withoutthe need of harsh and expensive Bronsted/Lewis

  已经开发了一种温和高效、离子液体辅助的绿色方案，用于在微波辐射下将苄醇脱水成相应的 (E)-芳基烯烃。该方法利用中性和可回收的离子液体（1-己基-3-甲基咪唑溴化物）作为试剂和溶剂，清洁地提供范围广泛的烯烃，而无需苛刻且昂贵的布朗斯台德/路易斯酸。该方法扩展到将苯甲醇的乙酰化/苯甲酰化衍生物有效转化为其相应的 (E)-芳基烯烃。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
• Delmas, M.; Bigot, Y. Le; Gaset, A., Synthetic Communications, 1981, vol. 11, # 2, p. 125 - 132
  作者：Delmas, M.、Bigot, Y. Le、Gaset, A.、Gorrichon, J. P.

  DOI：——

  日期：——
• Le Bigot, Y.; Delmas, M.; Gaset, A., Synthetic Communications, 1982, vol. 12, # 2, p. 107 - 112
  作者：Le Bigot, Y.、Delmas, M.、Gaset, A.

  DOI：——

  日期：——
• LE, BIGOT YVES;DELMAS, MICHEL;GASET, ANTOINE, TETRAHEDRON, 44,(1988) N 4, 1057-1072
  作者：LE, BIGOT YVES、DELMAS, MICHEL、GASET, ANTOINE

  DOI：——

  日期：——