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ethyl 4,11-dihydroxy-5,10-dioxo-2-phenylnaphtho[2,3-f][1]benzofuran-3-carboxylate | 89607-88-5

中文名称
——
中文别名
——
英文名称
ethyl 4,11-dihydroxy-5,10-dioxo-2-phenylnaphtho[2,3-f][1]benzofuran-3-carboxylate
英文别名
——
ethyl 4,11-dihydroxy-5,10-dioxo-2-phenylnaphtho[2,3-f][1]benzofuran-3-carboxylate化学式
CAS
89607-88-5
化学式
C25H16O7
mdl
——
分子量
428.398
InChiKey
WAAANUNUFJFJHK-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    4.46
  • 重原子数:
    32.0
  • 可旋转键数:
    3.0
  • 环数:
    5.0
  • sp3杂化的碳原子比例:
    0.08
  • 拓扑面积:
    114.04
  • 氢给体数:
    2.0
  • 氢受体数:
    7.0

反应信息

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文献信息

  • Insecticidal heterolignans—Tubuline polymerization inhibitors with activity against chewing pests
    作者:Jens Frackenpohl、Isabelle Adelt、Horst Antonicek、Christian Arnold、Patricia Behrmann、Nicole Blaha、Jutta Böhmer、Oliver Gutbrod、Roman Hanke、Sabine Hohmann、Marc van Houtdreve、Peter Lösel、Olga Malsam、Martin Melchers、Valentina Neufert、Elisabeth Peschel、Udo Reckmann、Thomas Schenke、Hans-Peter Thiesen、Robert Velten、Kathrin Vogelsang、Hans-Christoph Weiss
    DOI:10.1016/j.bmc.2009.01.042
    日期:2009.6
    Starting from natural product podophyllotoxin 1 substituted heterolignans were identified with promising insecticidal in vivo activity. The impact of substitution in each segment of the core structure was investigated in a detailed SAR study, and variation of substituents in both aromatic moieties afforded derivatives 5 and 43 with broad insecticidal activity against lepidopteran and coleopteran species. In vitro measurements supported by modeling studies indicate that heterolignans 3-134 act as tubuline polymerization inhibitors interacting with the colchicine-binding site. Insect specific structure-activity effects were observed showing that the insecticidal SAR described herein differs from reported cytotoxicity studies. (C) 2009 Elsevier Ltd. All rights reserved.
  • GORELIK, M. V.;MISHINA, E. V., ZH. ORGAN. XIMII, 1983, 19, N 10, 2185-2190
    作者:GORELIK, M. V.、MISHINA, E. V.
    DOI:——
    日期:——
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