1,4-anhydro-D-talitol | 124379-13-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 1,4-anhydro-D-talitol
• 英文别名: (2S,3R,4R)-2-[(1R)-1,2-dihydroxyethyl]oxolane-3,4-diol
• CAS: 124379-13-1
• 化学式: C₆H₁₂O₅
• 分子量: 164.158
• InChiKey: JNYAEWCLZODPBN-KAZBKCHUSA-N

物化性质

• 沸点：
  442.5±40.0 °C(Predicted)
• 密度：
  1.573±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,4-anhydro-D-talitol 、 丙酮 在 乙酰氯 作用下， 以 甲醇 为溶剂， 以55%的产率得到3,6-anhydro-1,2-4,5-di-O-isopropyliden-D-altritol
  参考文献：
  名称：

  Enantiomerically pure, highly functionalized tetrahydrofurans from simple carbohydrate precursors

  摘要：

  6-Bromo-6-deoxy-1,4-aldonolactones and 6-bromo-6-deoxy-alditols with D-galacto-, D-altro-, D-manno- and D-ido-configuration were selectively converted into hydroxylated tetrahydrofuran derivatives by simple heating in water. The 6-bromo-6-deoxy-D-altritol (10) and 6-bromo-6-deoxy-D-iditol (25) reacted even at room temperature. Likewise, the 6-bromo-2,6-dideoxy-aldonolactones with D-arabino- (29) and D-lyxo-configuration (31) gave the corresponding 2-deoxy-3,6-anhydrides, when heated in water. The rate of formation of the furan ring by intramolecular nucleophilic substitution was determined by the conformation of the bromopolyols in water.

  DOI：

  10.1016/s0040-4020(01)89337-6
• 作为产物：
  描述：

  6-bromo-6-deoxy-D-altrono-1,4-lactone 在 sodium tetrahydroborate 、 乙酰氯 作用下， 以 乙醇 、 水 为溶剂， 反应 4.0h， 生成 1,4-anhydro-D-talitol
  参考文献：
  名称：

  Enantiomerically pure, highly functionalized tetrahydrofurans from simple carbohydrate precursors

  摘要：

  6-Bromo-6-deoxy-1,4-aldonolactones and 6-bromo-6-deoxy-alditols with D-galacto-, D-altro-, D-manno- and D-ido-configuration were selectively converted into hydroxylated tetrahydrofuran derivatives by simple heating in water. The 6-bromo-6-deoxy-D-altritol (10) and 6-bromo-6-deoxy-D-iditol (25) reacted even at room temperature. Likewise, the 6-bromo-2,6-dideoxy-aldonolactones with D-arabino- (29) and D-lyxo-configuration (31) gave the corresponding 2-deoxy-3,6-anhydrides, when heated in water. The rate of formation of the furan ring by intramolecular nucleophilic substitution was determined by the conformation of the bromopolyols in water.

  DOI：

  10.1016/s0040-4020(01)89337-6

文献信息

• SOLID CATALYST FOR DEHYDRATION OF MANNITOL, AND METHOD FOR PRODUCING 2, 5-SORBITAN AND/OR ISOMANNIDE USING THIS CATALYST
  申请人：NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY

  公开号：US20190169205A1

  公开（公告）日：2019-06-06

  Provided is a solid acid catalyst which enables the production of isomannide and/or 2,5-sorbitan from mannitol with high yield and high safety at low cost. The mannitol may be derived from a cellulose and/or a hemicellulose. The solid acid catalyst for dehydration contains an acid type β-zeolite and/or a Y type zeolite.

  提供一种固体酸催化剂，可以以低成本高产率和高安全性从甘露醇生产异甘醇和/或2,5-山梨醇。甘露醇可以来源于纤维素和/或半纤维素。用于脱水的固体酸催化剂包含酸性β-沸石和/或Y型沸石。
• [EN] NITRIC OXIDE DONOR COMPOUNDS<br/>[FR] COMPOSÉS DONNEURS D'OXYDE NITRIQUE
  申请人：NICOX SA

  公开号：WO2009098113A1

  公开（公告）日：2009-08-13

  The invention relates to nitric oxide donors of the formula (I) and pharmaceutically acceptable salts or stereoisomers thereof : wherein A and A' are independently selected from the group consisting of H and -(X)s-Y with the proviso that at least one of A or A' is not H; wherein s is 0 or 1; X is selected from the group consisting of : -CO-, -COO-, -CONH- and -SO2- or (A); Y is straight or branched C1-C20 alkyl chain, preferably C1- C10 alkyl chain, substituted with one or two -ONO2; or C1-C6 alkylenoxy- C1-C5 alkyl wherein the alkyl group is substituted by one or two -ONO2 groups. The invention also provides novel compositions comprising at least one compound of the invention and at least one therapeutic agent.

  该发明涉及化学式(I)的一氧化氮供体及其药用盐或立体异构体：其中A和A'分别选自H和-(X)s-Y组成的组，但至少其中之一不是H；其中s为0或1；X选自以下组成的组：-CO-，-COO-，-CONH-和-SO2-或(A)；Y是直链或支链的C1-C20烷基链，优选C1-C10烷基链，取代有一个或两个-ONO2基团；或C1-C6烷氧基-C1-C5烷基，其中烷基基团取代有一个或两个-ONO2基团。该发明还提供了包括至少一种该发明化合物和至少一种治疗剂的新型组合物。
• METHOD FOR PRODUCING 2,6-DIOXABICYCLO-(3.3.0)-OCTANE-4,8-DIONE
  申请人：Dingerdissen Uwe

  公开号：US20110269977A1

  公开（公告）日：2011-11-03

  The invention relates to a method for producing 2,6-dioxabicyclo-(3.3.0)-octane-4,8-dione (I), comprising the oxidation of dianhydrohexitols (II-IV), or of corresponding hydroxy ketones, with an oxygen-containing gas in the presence of a catalyst composition, the reaction proceeding without the addition of halogen sources.

  本发明涉及一种生产2,6-二氧杂双环[3.3.0]辛烷-4,8-二酮(I)的方法，包括在催化剂组合物的存在下，通过使用含氧气体氧化二脱氢己糖(II-IV)或相应的羟基酮，而无需添加卤素源。
• [EN] NOVEL ACTIVATORS OF AMP-ACTIVATED PROTEIN KINASES<br/>[FR] NOUVEAUX ACTIVATEURS DE PROTÉINES KINASES ACTIVÉES PAR L'AMP
  申请人：DEBIOPHARM INTERNAT S A

  公开号：WO2016001224A1

  公开（公告）日：2016-01-07

  The present invention relates to a compound of structural Formula (I) or a salt thereof, which is useful as a direct AMPK activator. A further aspect of the present invention relates to use of said compound for the treatment of AMPK related diseases and to a pharmaceutical composition containing said compound.

  本发明涉及结构式(I)的化合物或其盐，其可作为直接的AMPK激活剂。本发明的另一个方面涉及使用该化合物治疗AMPK相关疾病以及含有该化合物的制药组合物。
• [EN] SYNTHESIS OF ISORSORBIDE MONONITRATE<br/>[FR] SYNTHESE DE MONONITRATE D'ISOSORBIDE
  申请人：CLARIANT LSM ITALIA SPA

  公开号：WO2001049692A1

  公开（公告）日：2001-07-12

  A method of synthesising a compound of formula (1), in which each of R?1 and R2¿ is independently selected from H or optionally substituted straight or branched chain C¿1?-C30 alkyl, C1-C30 carboxyalkyl, C1-C30 sulphoxyalkyl, C1-C30 alkoxy, C3-C30 cycloalkyl, C3-C30 carboxycycloalkyl, C3-C30 sulphoxycycloalkyl, C3-C30 cycloalkoxy, heterocyclic, carboxyheterocyclic, sulphoxyheterocyclic, oxyheterocylic, C3-C30 cycloalkenyl, carboxycycloalkenyl, sulphoxycycloalkenyl or cycloalkenoxy, C8-C30 cycloalkynyl, carboxycycloalkynyl, sulphoxycycloalkynyl or cycloalkynoxy, C2-C30 alkynyl, carboxyalkynyl, sulphoxyalkynyl or alkynoxy group, C4-C30 aromatic, carboxyaromatic, sulphoxyaromatic or aryloxy, C4-C30 heteroaromatic, carboxyheteroaromatic, sulphoxyheteroaromatic or heteroaryloxy group, wherein in any of the hereto atom-containing groups the hetero atom is selected from O, S, and N; comprises treating a compound of formula (2) with a reducing system effective to reduce preferentially the compound of formula (2) at the 2-position to produce the compound of formula (1), wherein the reducing system comprises (i) hydrogen in the presence of a platinum-containing catalyst, or (ii) a hybride source in the presence of a transition metal phthalocyanine or polyphthalocyanine in which the transition metal is iron and/or cobalt.

  一种合成化合物式（1）的方法，其中R1和R2各自独立地选择为H或可选地取代的直链或支链C1-C30烷基，C1-C30羧基烷基，C1-C30磺氧基烷基，C1-C30烷氧基，C3-C30环烷基，C3-C30羧基环烷基，C3-C30磺氧基环烷基，C3-C30环烷氧基，杂环，羧基杂环，磺氧基杂环，氧杂环，C3-C30环烯基，羧基环烯基，磺氧基环烯基或环烯氧基，C8-C30环炔基，羧基环炔基，磺氧基环炔基或环炔氧基，C2-C30炔基，羧基炔基，磺氧基炔基或炔氧基，C4-C30芳香基，羧基芳香基，磺氧基芳香基或芳氧基，C4-C30杂芳香基，羧基杂芳香基，磺氧基杂芳香基或杂芳氧基，其中在任何含有杂原子的基团中，杂原子选择自O、S和N；包括使用还原系统处理化合物式（2），该还原系统有效地选择性还原化合物式（2）的2位，以产生化合物式（1），其中还原系统包括（i）在铂催化剂存在下的氢，或（ii）在过渡金属菲酞酰菁或聚菲酞酰菁存在下的杂化源，其中过渡金属为铁和/或钴。