β-cyclodextrine-warfarin complex | 69441-12-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: β-cyclodextrine-warfarin complex
• 英文别名: warfarin-β-cyclodextrin complex
• CAS: 69441-12-9
• 化学式: C₁₉H₁₆O₄*C₄₂H₇₀O₃₅
• 分子量: 1443.33
• InChiKey: QCQRIRRWIMBBBY-ZQOBQRRWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -11.62
• 重原子数：
  100.0
• 可旋转键数：
  11.0
• 环数：
  24.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  621.56
• 氢给体数：
  22.0
• 氢受体数：
  39.0

反应信息

• 作为产物：
  描述：

  华法林 、 β-环糊精 以 乙醇 、 水 为溶剂， 生成 β-cyclodextrine-warfarin complex
  参考文献：
  名称：

  Preparation and evaluation of warfarin-β-cyclodextrin loaded chitosan nanoparticles for transdermal delivery

  摘要：

  The main objective of the present work was to prepare warfarin-beta-cyclodextrin (WAF-beta-CD) loaded chitosan (CS) nanoparticles for transdermal delivery. CS is a hydrophilic carrier therefore, to overcome the hydrophobic nature of WAF and allow its incorporation into CS nanoparticles, WAF was first complexed with beta-cyclodextrin (beta-CD). CS nanoparticles were prepared by ionotropic pre-gelation using tripolyphosphate (TPP). Morphology, size and structure characterization of nanoparticles were carried out using SEM, TEM and FTIR, respectively. Nanoparticles prepared with 3:1 CS:TPP weight ratio and 2 mg/ml final CS concentration were found optimum. They possessed spherical particles (35 +/- 12 nm diameter) with narrow size distribution (PDI = 0.364) and 94% entrapment efficiency. The in vitro release as well as the ex vivo permeation profiles of WAF-beta-CD from the selected nanoparticle formulation were studied at different time intervals up to 8 h. In vitro release of WAF-beta-CD from CS nanoparticles followed a Higuchi release profile whereas its ex vivo permeation (at pH 7.4) followed a zero order permeation profile. Results suggested that the developed WAF-beta-CD loaded CS carrier could offer a controlled and constant delivery of WAF transdermally. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carbpol.2012.06.056