sodium 2-((5,7-dibromoquinolin-8-yl)oxy)acetate | 1260620-04-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium 2-((5,7-dibromoquinolin-8-yl)oxy)acetate
• CAS: 1260620-04-9
• 化学式: C₁₁H₆Br₂NO₃*Na
• 分子量: 382.971
• InChiKey: XBKKOASCRLDXPA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.11
• 重原子数：
  18.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  62.25
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  sodium 2-((5,7-dibromoquinolin-8-yl)oxy)acetate 、 2-氯甲基吡啶盐酸盐 在 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Pyridin-2-ylmethyl 2-(5,7-dibromoquinolin-8-yl)oxyacetate
  参考文献：
  名称：

  A new Zn2+ chemosensor based on functionalized 8-hydroxylquinoline

  摘要：

  A new fluorescent Zn2+ chemosensor (3) based on functionalized 8-hydroxylquinoline has been synthesized and characterized. Compound 3 shows weak fluorescence in CH3CN-HEPES buffer solution (50 mM, pH 7.2 v/v = 1:9), but the fluorescence is significantly enhanced upon binding to Zn2+ through a zinc(II)-catalyzed ester hydrolysis reaction to form a highly emissive zinc(II) complex. This suggests that 3 can be served as a typical "switch-on" chemosensor with high selectivity for Zn2+ over other metal ions. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2010.08.009
• 作为产物：
  描述：

  5,7-二溴-8-羟基喹啉 在 四丁基氯化铵 、 potassium carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 水 、 乙腈 为溶剂， 生成 sodium 2-((5,7-dibromoquinolin-8-yl)oxy)acetate
  参考文献：
  名称：

  A new Zn2+ chemosensor based on functionalized 8-hydroxylquinoline

  摘要：

  A new fluorescent Zn2+ chemosensor (3) based on functionalized 8-hydroxylquinoline has been synthesized and characterized. Compound 3 shows weak fluorescence in CH3CN-HEPES buffer solution (50 mM, pH 7.2 v/v = 1:9), but the fluorescence is significantly enhanced upon binding to Zn2+ through a zinc(II)-catalyzed ester hydrolysis reaction to form a highly emissive zinc(II) complex. This suggests that 3 can be served as a typical "switch-on" chemosensor with high selectivity for Zn2+ over other metal ions. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.inoche.2010.08.009