| 952190-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• CAS: 952190-12-4
• 化学式: C₅₄H₅₅N₅NiO₂
• 分子量: 864.753
• InChiKey: GZMGGMFXVJILRZ-GHJOJRNZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  在 palladium on activated charcoal sodium tetrahydroborate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 1.0h， 以95%的产率得到
  参考文献：
  名称：

  Synthesis of new azido porphyrins and their reactivity in copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction with alkynes

  摘要：

  We report herein the preparation of two novel porphyrins substituted with an azido group born either on the para-position of one phenyl meso-susbtituent of a tetraaryl zinc porphyrin (1) or directly on the meso-position of a trisaryl nickel porphyrin (2). We studied the scope and the limitation the Huisgen cycloaddition reaction of these two porphyrins using different catalytic conditions. We observed that the carbene (SlMes)CuBr in THF/H2O 3:1 at 45 degrees C for 60 h gives almost quantitative yields for the reaction between I and different alkynes, but significantly lower yields with 2 probably due to its thermal instability. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.049
• 作为产物：
  描述：

  5-nitro-15-phenyl-10,20-di(3,5-di-tert-butylphenyl)porphyrin 在 nickel diacetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以97%的产率得到
  参考文献：
  名称：

  Synthesis of new azido porphyrins and their reactivity in copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction with alkynes

  摘要：

  We report herein the preparation of two novel porphyrins substituted with an azido group born either on the para-position of one phenyl meso-susbtituent of a tetraaryl zinc porphyrin (1) or directly on the meso-position of a trisaryl nickel porphyrin (2). We studied the scope and the limitation the Huisgen cycloaddition reaction of these two porphyrins using different catalytic conditions. We observed that the carbene (SlMes)CuBr in THF/H2O 3:1 at 45 degrees C for 60 h gives almost quantitative yields for the reaction between I and different alkynes, but significantly lower yields with 2 probably due to its thermal instability. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.07.049

文献信息

• Simple and Catalyst-Free Synthesis of <i>meso</i>-O-, -S-, and -C-Substituted Porphyrins
  作者：Qiang Chen、Yi-Zhou Zhu、Qiao-Jun Fan、Shao-Chun Zhang、Jian-Yu Zheng

  DOI：10.1021/ol500191j

  日期：2014.3.21

  A simple and efficient method for the meso-functionalization of porphyrin has been developed. Kinetic studies of meso-fluoro-, -chloro-, -bromo-, -iodo-, and -nitro-substituted porphyrins (Ni) with phenol reveal that the reaction undergoes a typical aromatic nucleophilic substitution (SNAr) process. This catalyst-free method can be performed with meso-brominated porphyrins and oxygen-, sulfur-, and carbon-based nucleophiles to achieve a wide variety of meso-substituted porphyrins.