1-chloro-2,5,8-triphenyl-7-octen-3-yn-2-ol | 323188-42-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 1-chloro-2,5,8-triphenyl-7-octen-3-yn-2-ol
• 英文别名: (E)-1-chloro-2,5,8-triphenyloct-7-en-3-yn-2-ol
• CAS: 323188-42-7
• 化学式: C₂₆H₂₃ClO
• 分子量: 386.921
• InChiKey: WYHHQRPZCJLUAS-JLHYYAGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-chloro-2,5,8-triphenyl-7-octen-3-yn-2-ol 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 以100%的产率得到1,2-epoxy-2,5,8-triphenyl-7-octen-3-yne
  参考文献：
  名称：

  Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines

  摘要：

  Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with alpha -halo carbonyl compounds and alpha -chloro imines, respectively. The reaction with substituted alpha -halo carbonyl compounds and alpha -chloro imines proved to be highly E diastereoselective.

  DOI：

  10.1002/1099-0690(200011)2000:22<3793::aid-ejoc3793>3.0.co;2-m
• 作为产物：
  描述：

  肉桂基氯 、 alkaline earth salt of/the/ methylsulfuric acid 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 1.17h， 生成 1-chloro-2,5,8-triphenyl-7-octen-3-yn-2-ol
  参考文献：
  名称：

  Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines

  摘要：

  Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with alpha -halo carbonyl compounds and alpha -chloro imines, respectively. The reaction with substituted alpha -halo carbonyl compounds and alpha -chloro imines proved to be highly E diastereoselective.

  DOI：

  10.1002/1099-0690(200011)2000:22<3793::aid-ejoc3793>3.0.co;2-m

文献信息

• Lithiation of Cinnamyl Chloride: Stereoselective Synthesis of Propargylic Oxiranes and Aziridines
  作者：Saverio Florio、Luigino Troisi、Vito Capriati、Giovanna Suppa

  DOI：10.1002/1099-0690(200011)2000:22<3793::aid-ejoc3793>3.0.co;2-m

  日期：2000.11

  Propargylic oxiranes 4a-e and aziridines 8a-c have been prepared from cinnamyl chloride through lithiation-alkylation with alpha -halo carbonyl compounds and alpha -chloro imines, respectively. The reaction with substituted alpha -halo carbonyl compounds and alpha -chloro imines proved to be highly E diastereoselective.