2,3-Diphenyl-1-hydroxypyrrolo<1,2-b>pyridazine | 135613-52-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 2,3-Diphenyl-1-hydroxypyrrolo<1,2-b>pyridazine
• 英文别名: 6,7-Diphenylpyrrolo[1,2-b]pyridazin-5-ol
• CAS: 135613-52-4
• 化学式: C₁₉H₁₄N₂O
• 分子量: 286.333
• InChiKey: LTDRJIXOLRMZCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3-Diphenyl-1-hydroxypyrrolo<1,2-b>pyridazine 在 三氯氧磷 作用下， 反应 27.0h， 生成 diethyl 6,7-diphenylpyrrolo[1,2-b]pyridazin-5-yl phosphate
  参考文献：
  名称：

  Synthesis of 5-Substituted Pyrrolo[1,2-b]pyridazines with Antioxidant Properties

  摘要：

  5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.

  DOI：

  10.1002/1521-4184(200101)334:1<21::aid-ardp21>3.0.co;2-w
• 作为产物：
  描述：

  哒嗪 、 二苯基环丙烯酮 以 甲醇 为溶剂， 反应 1.0h， 以70%的产率得到2,3-Diphenyl-1-hydroxypyrrolo<1,2-b>pyridazine
  参考文献：
  名称：

  Indolizines. 5. Preparation and structural assignments of azaindolizinols

  摘要：

  Diphenylcyclopropenone reacts smoothly with a variety of aromatic N-heterocycles to provide aza- and benzazaindolizinols. Although known in the literature, these compounds had been assigned incorrect structures. The preparation and physical properties of a number of derivatives, along with unequivocal assignments of structure based on a variety of NMR techniques, is described herein.

  DOI：

  10.1021/jo00019a024