(3-iodobenzyl)(phenyl)sulfane | 470475-51-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (3-iodobenzyl)(phenyl)sulfane
• 英文别名: 1-Iodo-3-(phenylsulfanylmethyl)benzene
• CAS: 470475-51-5
• 化学式: C₁₃H₁₁IS
• 分子量: 326.201
• InChiKey: LWSOTPNVIUIQRE-UHFFFAOYSA-N

物化性质

• 沸点：
  388.6±35.0 °C(Predicted)
• 密度：
  1.62±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (3-iodobenzyl)(phenyl)sulfane 在 四(三苯基膦)钯 ruthenium(IV) oxide 、 sodium periodate 、 copper(l) iodide 、 十六烷基三丁基溴化磷 、 二异丙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 5.0h， 生成 4-methyl-N-[[3-[2-[3-[2-[1-[2-[2-[3-[2-[3-[[N-(4-methylphenyl)sulfonyl-S-phenylsulfonimidoyl]methyl]phenyl]ethynyl]phenyl]ethynyl]naphthalen-1-yl]naphthalen-2-yl]ethynyl]phenyl]ethynyl]phenyl]methyl-oxo-phenyl-lambda6-sulfanylidene]benzenesulfonamide
  参考文献：
  名称：

  Sulfoximine Version of Double Elimination Protocol for Synthesis of Chiral Acetylenic Cyclophanes

  摘要：

  A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields of the desired cyclophanes. Thus, arylene-ethynylene moieties with terminal sulfoximine or formyl functions are linked to binaphthyl cores and these building blocks are then subjected to double elimination reaction. The desired macrocycles are obtained in up to 35% yield. The corresponding Sonogashira coupling fails to afford cyclophanes indicative of effectiveness of the double elimination methodology.

  DOI：

  10.1002/1521-3765(20020503)8:9<2005::aid-chem2005>3.0.co;2-i
• 作为产物：
  描述：

  3-碘苯甲醇 、 二苯二硫醚 在 三丁基膦 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以95%的产率得到(3-iodobenzyl)(phenyl)sulfane
  参考文献：
  名称：

  Sulfoximine Version of Double Elimination Protocol for Synthesis of Chiral Acetylenic Cyclophanes

  摘要：

  A new strategy for constructing enantiopure acetylenic cyclophanes is described on the basis of one-pot double elimination reaction starting from dialdehydes and bis(sulfoximine)s. In this case, the conventional sulfone protocol affords poorer yields of the desired cyclophanes. Thus, arylene-ethynylene moieties with terminal sulfoximine or formyl functions are linked to binaphthyl cores and these building blocks are then subjected to double elimination reaction. The desired macrocycles are obtained in up to 35% yield. The corresponding Sonogashira coupling fails to afford cyclophanes indicative of effectiveness of the double elimination methodology.

  DOI：

  10.1002/1521-3765(20020503)8:9<2005::aid-chem2005>3.0.co;2-i

文献信息

• [EN] DISULPHIDE COMPOUNDS<br/>[FR] COMPOSÉS DISULFURE
  申请人：NEEM BIOTECH LTD

  公开号：WO2020157463A1

  公开（公告）日：2020-08-06

  Disulphide compounds of Formula (I) where Y is sulphuryl or sulphinyl Z is phenyl or substituted phenyl and the other variables are as defined in the claims; pharmaceutical compositions comprising these compounds and methods for making these compounds. These compounds are useful in therapeutic methods for treating microbial infection, inflammation and reducing the formation of blood clots and have non-therapeutic use as antimicrobial agents, anti-inflammatory agents and as anti-thrombotic agents.

  化合物的二硫化物，其中Y是磺酰基或亚砜基，Z是苯基或取代苯基，其他变量如索要中所定义；包括这些化合物的药物组合物以及制备这些化合物的方法。这些化合物在治疗微生物感染、炎症和减少血栓形成的治疗方法中非常有用，并且在非治疗用途中可用作抗菌剂、抗炎剂和抗血栓剂。
• DISULPHIDE COMPOUNDS
  申请人：Neem Biotech Limited

  公开号：EP3917909A1

  公开（公告）日：2021-12-08