cis-2-Methyl-cyclopropan-carbonsaeure-methylester | 860017-72-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-2-Methyl-cyclopropan-carbonsaeure-methylester
• 英文别名: methyl (1R,2S)-2-methylcyclopropane-1-carboxylate
• CAS: 860017-72-7
• 化学式: C₆H₁₀O₂
• 分子量: 114.144
• InChiKey: KHHQNCNOFKTABM-CRCLSJGQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Heterobicyclic metalloprotease inhibitors
  申请人：Hochgurtel Matthias

  公开号：US20080221083A1

  公开（公告）日：2008-09-11

  The present invention relates generally to amide containing heterobicyclic containing pharmaceutical agents, and in particular, to amide containing heterobicyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterobicyclic MMP-3 and/or MMP-13 inhibiting compounds, that exhibit an increased potency and selectivity in relation to currently known MMP-13 and MMP-3 inhibitors.