N-(tert-butoxycarbonyl)-L-valine-benzhydrylamide | 119094-33-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(tert-butoxycarbonyl)-L-valine-benzhydrylamide
• 英文别名: tert-butyl N-[(2S)-1-(benzhydrylamino)-3-methyl-1-oxobutan-2-yl]carbamate
• CAS: 119094-33-6
• 化学式: C₂₃H₃₀N₂O₃
• 分子量: 382.503
• InChiKey: FRVXCEKIUUBVFB-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(tert-butoxycarbonyl)-L-valine-benzhydrylamide 在 劳森试剂 作用下， 以 四氢呋喃 为溶剂， 生成 N-(tert-butoxycarbonyl)-L-valine-benzhydrylthioamide
  参考文献：
  名称：

  Fine-tuning catalytic activity and selectivity—[Rh(amino acid thioamide)] complexes for efficient ketone reduction

  摘要：

  Amino acid-derived thioamides are prepared and evaluated as ligands in the rhodium-catalyzed asymmetric transfer hydrogenation of ketones in 2-propanol. It is found that increasing the steric bulk at the C-terminus of the ligand had a positive impact on both activity and selectivity in the reduction reaction. In order to find the optimum catalyst, a study is performed on a series of thioamide ligands having substituents of varying size. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.116
• 作为产物：
  描述：

  N-Boc-L-缬氨酸 在 N-甲基吗啉 作用下， 以 二氯甲烷 为溶剂， 反应 1.33h， 生成 N-(tert-butoxycarbonyl)-L-valine-benzhydrylamide
  参考文献：
  名称：

  简单的高度模块化的无环胺催化的酮直接向硝基烯烃对映选择性加成。

  摘要：

  简单，高度模块化的伯氨基酸衍生物可催化具有高立体控制性的酮直接对映选择性加成至硝基烯烃，并以高产率提供相应的羟醛产物，其产率最高> 38 1 dr，最高ee可达99％。

  DOI：

  10.1039/b514783m

文献信息

• HTLV-III(LAV) Envelope peptides
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP0247557A2

  公开（公告）日：1987-12-02

  Synthetic peptides containing the epitopic sequence HTLV env (578-608) of the formula: W-X-Ala-Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-­Gln-Gln-Leu-Leu-Gly-Ile-Trp-Gly-Cys-Ser-Gly-Lys-Leu-­Ile-Cys-Thr-Thr-Ala-Val-Y-Z            (I) wherein W is H-, Cys- or Tyr-, X is a bond or a sub-sequence of one or more amino acids starting from the carboxyl terminus of HLTV-III env (557-577); Y is a bond or a sub-sequence of one or more amino acids starting from the amino terminus of HTLV-III env (609-641); and Z is -OH, -NHÊ -Cys-NHÊ, provided however that one of X and Y is a bond, are disclosed which peptides are useful as reagents in immunoassays for detection of AIDS antibodies, as immunogens for eliciting polyclonal or monoclonal anti­bodies against AIDS virus env protein and as components in an AIDS vaccine.

  含有 HTLV env (578-608) 表位序列的合成肽，其结构式为 W-X-Ala-Arg-Ile-Leu-Ala-Val-Glu-Arg-Tyr-Leu-Lys-Asp-Gln-Gln-Leu-Gly-Ile-Trp-Gly-Cys-Ser-Gly-Lys-Leu-Ile-Cys-Thr-Thr-Ala-Val-Y-Z (I) 其中 W 是 H-、Cys- 或 Tyr-，X 是一个键或一个或多个氨基酸的子序列，从 HLTV-III env（557-577）的羧基末端开始；Y 是一个键或一个或多个氨基酸的子序列，从 HTLV-III env（609-641）的氨基末端开始；这些多肽可用作检测艾滋病抗体的免疫测定试剂、诱导针对艾滋病病毒 env 蛋白的多克隆或单克隆抗体的免疫原以及艾滋病疫苗的成分。
• US4957737A
  申请人：——

  公开号：US4957737A

  公开（公告）日：1990-09-18
• Fine-tuning catalytic activity and selectivity—[Rh(amino acid thioamide)] complexes for efficient ketone reduction
  作者：Katrin Ahlford、Madeleine Livendahl、Hans Adolfsson

  DOI：10.1016/j.tetlet.2009.08.116

  日期：2009.11

  Amino acid-derived thioamides are prepared and evaluated as ligands in the rhodium-catalyzed asymmetric transfer hydrogenation of ketones in 2-propanol. It is found that increasing the steric bulk at the C-terminus of the ligand had a positive impact on both activity and selectivity in the reduction reaction. In order to find the optimum catalyst, a study is performed on a series of thioamide ligands having substituents of varying size. (C) 2009 Elsevier Ltd. All rights reserved.
• Simple highly modular acyclic amine-catalyzed direct enantioselective addition of ketones to nitro-olefins
  作者：Yongmei Xu、Armando Córdova

  DOI：10.1039/b514783m

  日期：——

  Simple, highly modular primary amino acid derivatives catalyze the direct enantioselective addition of ketones to nitro-olefins with high stereocontrol and furnish the corresponding aldol products in high yield with up to >38 1 dr and up to 99% ee.

  简单，高度模块化的伯氨基酸衍生物可催化具有高立体控制性的酮直接对映选择性加成至硝基烯烃，并以高产率提供相应的羟醛产物，其产率最高> 38 1 dr，最高ee可达99％。