5-azido-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-one | 151993-69-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-azido-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-one
• 英文别名: 5-Azido-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-one；5-azido-3,6-diphenyl-2-sulfanylidene-[1,3]thiazolo[4,5-d]pyrimidin-7-one
• CAS: 151993-69-0
• 化学式: C₁₇H₁₀N₆OS₂
• 分子量: 378.438
• InChiKey: LELABEZFPDLMPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-azido-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-one 在 sodium dithionite 作用下， 以 乙醇 、 水 为溶剂， 反应 1.0h， 以50%的产率得到5-amino-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-one
  参考文献：
  名称：

  Potential anti-microbials. I. Synthesis and structure-activity studies of some new thiazolo[4,5-d]pyrimidine derivatives

  摘要：

  The synthesis of several 2,3-dihydro-3,6-diaryl-5-mercapto-2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones and related compounds are discussed. Some members of the series displayed broad in vitro anti-bacterial and anti-fungal activities. Three compounds were screened for anti-HIV potency but were inactive.

  DOI：

  10.1016/0223-5234(93)90001-u
• 作为产物：
  描述：

  2,3-dihydro-3,6-diphenyl-5-mercapto-2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-one 在 sodium azide 、 五氯化磷 、 三氯氧磷 作用下， 以 丙酮 为溶剂， 反应 5.0h， 生成 5-azido-2,3-dihydro-3,6-diphenyl-2-thioxothiazolo<4,5-d>pyrimidin-7(6H)-one
  参考文献：
  名称：

  Potential anti-microbials. I. Synthesis and structure-activity studies of some new thiazolo[4,5-d]pyrimidine derivatives

  摘要：

  The synthesis of several 2,3-dihydro-3,6-diaryl-5-mercapto-2-thioxothiazolo[4,5-d]pyrimidin-7(6H)-ones and related compounds are discussed. Some members of the series displayed broad in vitro anti-bacterial and anti-fungal activities. Three compounds were screened for anti-HIV potency but were inactive.

  DOI：

  10.1016/0223-5234(93)90001-u