3-Isopropyl-2-thiabicyclo<0.3.3>octadien-(3.5(1)) | 114331-75-8

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-Isopropyl-2-thiabicyclo<0.3.3>octadien-(3.5(1))
• 英文别名: 2-isopropyl-5,6-dihydro-4H-cyclopenta[b]thiophene；2-propan-2-yl-5,6-dihydro-4H-cyclopenta[b]thiophene
• CAS: 114331-75-8
• 化学式: C₁₀H₁₄S
• 分子量: 166.287
• InChiKey: BFBYYUSWSWWJLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  28.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• [EN] SULFONYLUREA DERIVATIVES AND USES THEREOF<br/>[FR] DÉRIVÉS DE SULFONYLURÉE ET LEURS UTILISATIONS
  申请人：NODTHERA LTD

  公开号：WO2020249664A1

  公开（公告）日：2020-12-17

  The present disclosure relates to compounds of Formula (I) and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for inhibiting the maturation of cytokines of the IL-1 family by inhibiting inflammasomes and may be used in the treatment of disorders in which inflammasome activity is implicated, such as inflammatory, autoinflammatory and autoimmune diseases and cancers.

  本公开涉及式(I)化合物及其前药、药用可接受盐、药物组合物、使用方法和制备方法。所公开的化合物可用于通过抑制炎症小体来抑制IL-1家族细胞因子的成熟，并可用于治疗炎症、自身炎症和自身免疫疾病以及癌症等炎症小体活性涉及的疾病。
• OPIOID RECEPTOR LIGANDS AND METHODS OF USING AND MAKING SAME
  申请人：Yamashita Dennis

  公开号：US20120245181A1

  公开（公告）日：2012-09-27

  This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.

  这种应用描述了可以作为阿片受体配体的化合物，这些化合物可以用于治疗例如疼痛和与疼痛相关的疾病。
• Inhibitors of Human Immunodeficiency Virus Replication
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20130237499A1

  公开（公告）日：2013-09-12

  The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

  该披露通常涉及到公式I的化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。该披露提供了HIV的新型抑制剂，包含这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Tsantrizos Youla S.

  公开号：US20110118249A1

  公开（公告）日：2011-05-19

  Compounds of formula (I): wherein c, X, Y, R 2 , R 4 and R 5 are defined herein, are useful as inhibitors of HIV replication.

  式(I)的化合物：其中c、X、Y、R2、R4和R5的定义如本文所述，可用作HIV复制的抑制剂。
• Opioid receptor ligands and methods of using and making same
  申请人：TREVENA, INC.

  公开号：US10588898B2

  公开（公告）日：2020-03-17

  This application describes compounds that can act as opioid receptor ligands, which compounds can be used in the treatment of, for example, pain and pain related disorders.

  本申请介绍了可作为阿片受体配体的化合物，这些化合物可用于治疗疼痛和疼痛相关疾病等。