platinum(II) tetraphenyltetranaphthoporphyrin | 166174-13-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: platinum(II) tetraphenyltetranaphthoporphyrin
• 英文别名: PtTPTNP
• CAS: 166174-13-6
• 化学式: C₇₆H₄₄N₄Pt
• 分子量: 1208.29
• InChiKey: PLGSANBMSPUWDE-ZTCHSXRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为反应物：
  描述：

  platinum(II) tetraphenyltetranaphthoporphyrin 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  “Clickable” Polymer-Caged Nanobins as a Modular Drug Delivery Platform

  摘要：

  Modularly clickable polymer-caged nanobins (PCNs) were prepared from liposome templates using a drop-in cholesterol-modified poly(acrylic acid) reagent followed by cross-linking with alkyne-functionalized diamine linker that allows for the conjugation of azide-modified targeting ligands via click ligation. These PCNs possess pH-responsive characteristics that can be used to trigger the release of encapsulated doxorubicin (DXR) payload inside the liposomal core under mild acidic conditions. After click-conjugation with azide-modified folate as an active targeting ligand, the resulting folate-conjugated, DXR-loaded PCNs (f-PCNDXR) demonstrated enhanced potency to folate receptor (FR)-positive tumor cells such as KB and OvCa432 over FR-negative MCF7 cells. f-PCNDXR can readily discriminate FR-positive tumor cells as a function of the level of cellular FR-expression, showing different degrees of potentiation in each cell. With both targeting functionalities and pH-sensitive drug-releasing triggers, f-PCNDXR was fifty-times more potent than the untargeted agent toward cancer cells that overexpress the folate target receptors.

  DOI：

  10.1021/ja9017336
• 作为产物：
  描述：

  在 哌啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 platinum(II) tetraphenyltetranaphthoporphyrin
  参考文献：
  名称：

  “Clickable” Polymer-Caged Nanobins as a Modular Drug Delivery Platform

  摘要：

  Modularly clickable polymer-caged nanobins (PCNs) were prepared from liposome templates using a drop-in cholesterol-modified poly(acrylic acid) reagent followed by cross-linking with alkyne-functionalized diamine linker that allows for the conjugation of azide-modified targeting ligands via click ligation. These PCNs possess pH-responsive characteristics that can be used to trigger the release of encapsulated doxorubicin (DXR) payload inside the liposomal core under mild acidic conditions. After click-conjugation with azide-modified folate as an active targeting ligand, the resulting folate-conjugated, DXR-loaded PCNs (f-PCNDXR) demonstrated enhanced potency to folate receptor (FR)-positive tumor cells such as KB and OvCa432 over FR-negative MCF7 cells. f-PCNDXR can readily discriminate FR-positive tumor cells as a function of the level of cellular FR-expression, showing different degrees of potentiation in each cell. With both targeting functionalities and pH-sensitive drug-releasing triggers, f-PCNDXR was fifty-times more potent than the untargeted agent toward cancer cells that overexpress the folate target receptors.

  DOI：

  10.1021/ja9017336
• 作为试剂：
  描述：

  1,9-diphenylnona-2,7-diene-1,9-dione 在 lithium tetrafluoroborate 、 tris(2,2'‐bipyridine)ruthenium(II) hexafluorophosphate 、 platinum(II) tetraphenyltetranaphthoporphyrin 、 2,5,8,11-四叔丁基苝 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 10.0h， 以81.818%的产率得到
  参考文献：
  名称：

  通过三重态聚变上转换使用红外光进行光氧化还原催化

  摘要：

  光氧化还原催化的最新进展使得实现各种具有挑战性的合成转化、聚合和表面改性成为可能1-3。所有这些反应都需要紫外线或可见光刺激。然而，可见光照射的使用具有内在的挑战。例如，可见光通过大多数反应介质的穿透力非常低，导致大规模反应出现问题。此外，反应物可以与光催化剂竞争吸收入射光，从而限制了反应的范围。这些问题可以通过使用近红外光来克服，近红外光具有更高的穿透深度，可穿透各种介质，尤其是生物组织4。在这里，我们通过利用三重态聚变上转换的光物理过程展示了红外辐射下的各种光氧化还原转换，这是一种将两个低能光子转换为高能光子的机制。我们表明这是适用于广泛的光氧化还原反应的一般策略。我们通过成对操纵敏化剂和湮灭剂来调整上转换组件以调整输出光，从低能红外光中获取橙光和蓝光。我们进一步证明了湮灭剂本身可以用作光催化剂，从而简化了反应。这种方法能够使用低能红外光通过几个不透明的屏障催化高能转化。

  DOI：

  10.1038/s41586-018-0835-2

文献信息

• [EN] FIBROBLAST ACTIVATION PROTEIN LIGANDS FOR TARGETED DELIVERY APPLICATIONS<br/>[FR] LIGANDS DE PROTÉINE D'ACTIVATION DES FIBROBLASTES POUR APPLICATIONS D'ADMINISTRATION CIBLÉE
  申请人：PHILOCHEM AG

  公开号：WO2021160825A1

  公开（公告）日：2021-08-19

  The present invention relates to ligands of Fibroblast Activation Protein (FAP) for the active delivery of various payloads (e.g. cytotoxic drugs, radionuclides, fluorophores, proteins and immunomodulators) at the site of disease. In particular, the present invention relates to the development of FAP ligands for targeting applications, in particular diagnostic methods and/or methods for therapy or surgery in relation to a disease or disorder, such as cancer, inflammation or another disease characterized by overexpression of FAP.

  本发明涉及纤维母细胞活化蛋白（FAP）的配体，用于在疾病部位主动传递各种有效载荷（例如细胞毒药物、放射性核素、荧光染料、蛋白质和免疫调节剂）。具体而言，本发明涉及开发用于靶向应用的FAP配体，特别是用于诊断方法和/或与疾病或疾病相关的治疗或手术方法，如癌症、炎症或另一种以FAP过表达为特征的疾病。
• Photophysical Properties of Near-Infrared Phosphorescent π-Extended Platinum Porphyrins
  作者：Jonathan R. Sommer、Abigail H. Shelton、Anand Parthasarathy、Ion Ghiviriga、John R. Reynolds、Kirk S. Schanze

  DOI：10.1021/cm202241e

  日期：2011.12.27

  comprehensive photophysical study is reported on a family of π-extended platinum(II) porphyrin complexes. The platinum(II) complexes are synthesized from the corresponding free base porphyrins by treatment with platinum(II) acetate in hot benzonitrile, affording the complexes in considerably higher yield than by reaction with platinum(II) chloride. A quantitative study of the absorption and luminescence

  据报道，对一类π-延伸的铂（II）卟啉配合物进行了全面的光物理研究。通过在热的苄腈中用乙酸铂（II）处理，由相应的游离碱卟啉合成铂（II）配合物，与通过与氯化铂（II）的反应相比，得到的配合物收率要高得多。提出了对金属卟啉的吸收和发光性质的定量研究。包括四芳基苯并卟啉，四芳基萘和四芳基卟啉的系列在近红外区域的773、890和1020 nm处显示有效的磷光，量子产率分别为0.35、0.15和0.08。三重态寿命和磷光产率随发射波长的增加而降低，这与能隙定律行为一致。检查了一组六种具有不同内消旋取代基的Pt-四苯并卟啉（TBP）。Pt-TBPs表现出有效的磷光，λ最大波长约为770 nm，量子产率在0.26-0.49之间，具体取决于取代模式。结果表明，与5,10,15,20-四芳基苯并卟啉相比，5,15-二芳基苯并卟啉具有高50-60％的磷光发射率。对于铂（II）5,15-二芳基苯并卟啉观察到最高的磷光量子效率，其在770
• 有机金属化合物、包括其的有机发光装置和包括该有机发光装置的设备
  申请人：三星显示有限公司

  公开号：CN110655523A

  公开（公告）日：2020-01-07

  一种有机金属化合物由式1表示。一种有机发光装置包括：第一电极；面向第一电极的第二电极；以及在第一电极和第二电极之间的有机层，有机层包括发光层和至少一种由式1表示的有机金属化合物。一种设备包括上述有机发光装置。
• Synthesis of Alkyne-Terminated PCDA Linker for Applying Click Chemistry on PDA Layers
  作者：Yoon-Sik Lee、Ja-Young Namgung、Bong-Hyun Jun

  DOI：10.1055/s-0029-1219178

  日期：2010.2

  An alkyne-terminated PCDA (10,12-pentacosadiynoic acid) linker, which can undergo a simple click reaction with azide compounds, was synthesized for the purpose of immobilizing various kinds of biomolecular surface ligands on PDA (polydiacetylene) layers. In order to confirm the ability of the linker compound to anchor azide-modified surface ligands, we carried out a model ­reaction with benzyl azide under typical click-reaction conditions. We were able to confirm that the model reaction proceeded smoothly by observing the color change of PDA, including its thermochromic reversibility.

  为了将各种生物分子表面配体固定在PDA（聚二乙炔）层上，合成了一种可以与叠氮化合物发生简单点击反应的炔烃封端PCDA（10,12-二十五碳二炔酸）连接体。为了确认连接化合物锚定叠氮修饰表面配体的能力，我们在典型的点击反应条件下与苄基叠氮进行了模型反应。通过观察PDA的颜色变化，包括其热致变色可逆性，我们能够确认模型反应顺利进行。
• Molecular and Morphological Influences on the Open Circuit Voltages of Organic Photovoltaic Devices
  作者：M. Dolores Perez、Carsten Borek、Stephen R. Forrest、Mark E. Thompson

  DOI：10.1021/ja9007722

  日期：2009.7.8

  We explore the dependence of the dark current Of C-60-based organic photovoltaic (OPV) cells on molecular composition and the degree of intermolecular interaction of several molecular donor materials. The saturation dark current density, J(S) is an important factor in determining the open circuit voltage, V-oc. The V-oc values of OPVs show a strong inverse correlation with J(S). Donor materials that show evidence for aggregation in their thin-film absorption spectra and polycrystallinity in thin film X-ray diffraction result in a high dark current, and thus a low V-oc. In contrast, donor materials with structures that hinder intermolecular pi-interaction give amorphous thin films and reduced values of J(S), relative to donors with strong intermolecular pi-interactions, leading to a high V-oc. This work provides guidance for the design of materials and device architectures that maximize OPV cell power conversion efficiency.