(E)-methyl 2-methylene-5-phenylpent-4-enoate | 1619998-85-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-methyl 2-methylene-5-phenylpent-4-enoate
• 英文别名: methyl (E)-2-methylidene-5-phenylpent-4-enoate
• CAS: 1619998-85-4
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: QNUCRBNCOPNKTD-UXBLZVDNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.82
• 重原子数：
  15.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  反式肉桂醛 在 二氢吡啶 、 L-脯氨酸 作用下， 以 甲醇 为溶剂， 反应 13.0h， 生成 (E)-methyl 2-methylene-5-phenylpent-4-enoate
  参考文献：
  名称：

  高产的手性和非手性α-取代的丙烯酸酯的顺序一锅合成通过无金属还原偶合反应†

  摘要：

  通过无金属还原偶联反应的顺序一锅法结合然后进行Eschenmoser甲基化，可以实现高产率合成取代的手性和非手性α-取代的丙烯酸酯的一般方法。在醇溶剂存在下，Eschenmoser盐能成功地使脯氨酸催化Meldrum的酸，醛和Hantzsch酯的甲基化反应。本文中，我们显示了由手性/非手性α-取代丙烯酸酯高特权合成的合成原料，并显示它们是药物和天然产物合成中非常好的中间体。

  DOI：

  10.1039/c4ob00667d

文献信息

• Process for the production of living radical polymers and polymers
  申请人：Yamago Shigeru

  公开号：US20060135711A1

  公开（公告）日：2006-06-22

  A process for producing a living radical polymer characterized in that a vinyl monomer is polymerized with use of an organotellurium compound represented by the formula (1) and an azo type polymerization initiator, and the living radical polymer obtainable by the process wherein R 1 is C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 2 and R 3 are each a hydrogen atom or C 1 -C 8 alkyl, and R 4 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, oxycarbonyl or cyano.

  使用由公式（1）表示的有机碲化合物和偶氮类聚合引发剂聚合乙烯单体的生活自由基聚合物的生产方法，其中所述生活自由基聚合物可通过该方法获得 其中R1为C1-C8烷基，芳基，取代芳基或芳香杂环基，R2和R3分别为氢原子或C1-C8烷基，R4为芳基，取代芳基，芳香杂环基，酰基，氧羰基或氰基。
• BIOMASS-DERIVED METHYL METHACRYLATE AND CORRESPONDING MANUFACTURING METHOD, USES AND POLYMERS
  申请人：Dubois Jean-Luc

  公开号：US20110318515A1

  公开（公告）日：2011-12-29

  The invention relates to methyl methacrylate characterized in that at least one portion of the carbons thereof is biologically sourced and, more specifically, in that it contains between 0.2×10 −10 and 1.2×10 −10 wt.-% of 14 C in relation to total carbon weight according to the ASTM D6866 standard. The preparation method comprises the use of acetone cyanohydrin as a raw material, said acetone cyanohydrin being obtained by condensing cyanohydric acid on acetone, and the methyl methacrylate is prepared using a process involving the addition of methanol. According to the invention, at least one from among the acetone, cyanohydric acid and methanol is obtained by means of a reaction or series of reactions involving the biomass.

  该发明涉及甲基丙烯酸甲酯，其特征在于其碳的至少一部分是生物来源的，更具体地说，根据ASTM D6866标准，它含有相对于总碳重量的14C在0.2×10 −10 和1.2×10 −10 wt.-%之间。制备方法包括使用丙酮氰水合物作为原料，所述丙酮氰水合物是通过将氰酸在丙酮上缩合而获得的，而甲基丙烯酸甲酯是使用涉及甲醇添加的过程制备的。根据该发明，丙酮、氰酸和甲醇中的至少一种是通过涉及生物质的反应或一系列反应获得的。
• Sequential Palladium-Catalyzed Allylic Alkylation/retro-Dieckmann Fragmentation Strategy for the Synthesis of α-Substituted Acrylonitriles
  作者：Tania Katsina、Sachi Prem Sharma、Roberto Buccafusca、Derek J. Quinn、Thomas S. Moody、Stellios Arseniyadis

  DOI：10.1021/acs.orglett.9b03522

  日期：2019.12.6

  A straightforward synthesis of α-substituted acrylonitriles is described using 4-cyano-3-oxotetrahydro-thiophene (c-THT) as an acrylonitrile surrogate. This unprecedented two-step sequence featuring a palladium-catalyzed allylic alkylation (Pd-AA) and a retro-Dieckmann fragmentation provides a general entry into diversely substituted 1,4-dienes.

  描述了使用4-氰基-3-氧代四氢噻吩（c-THT）作为丙烯腈替代物直接合成α-取代的丙烯腈的方法。这一前所未有的两步序列以钯催化的烯丙基烷基化（Pd-AA）和Dieckmann逆向断裂为特征，为进入各种取代的1,4-二烯提供了一般途径。
• POLYCARBONATE RESIN COMPOSITION, MOLDED ARTICLE, POLYCARBONATE RESIN, AND END-CAPPING AGENT FOR POLYCARBONATE RESIN
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：US20200115496A1

  公开（公告）日：2020-04-16

  A polycarbonate resin composition, a molded article, a polycarbonate resin, and an end-capping agent for polycarbonate resins are provided. The polycarbonate resin composition contains: a polycarbonate resin having a terminal structure represented by Formula (A) and having a viscosity average molecular weight from 1×10 4 to 5×10 4 , and a stabilizer. In Formula (A), R 1 is selected from the group consisting of a hydrogen atom, halogen atoms, linear alkyl groups having from 1 to 9 carbons, branched alkyl groups having from 3 to 9 carbons, linear alkenyl groups having from 2 to 9 carbons, branched alkenyl groups having from 3 to 9 carbons, and aryl groups having from 6 to 12 carbons; and R 2 to R 7 are each independently selected from the group consisting of a hydrogen atom, alkyl groups having from 1 to 9 carbons, and alkoxy groups having from 1 to 9 carbons.

  提供聚碳酸酯树脂组合物、成型品、聚碳酸酯树脂和聚碳酸酯树脂封端剂。聚碳酸酯树脂组合物包含：具有由式（A）表示的末端结构和粘度平均分子量为1×104到5×104的聚碳酸酯树脂，以及稳定剂。在式（A）中，R1选择自氢原子、卤素原子、具有1到9个碳原子的直链烷基、具有3到9个碳原子的支链烷基、具有2到9个碳原子的直链烯基、具有3到9个碳原子的支链烯基和具有6到12个碳原子的芳基组成的群；而R2到R7分别独立地选择自氢原子、具有1到9个碳原子的烷基和具有1到9个碳原子的烷氧基组成的群。
• NANOPARTICLES CARRYING ANTIBIOTICS
  申请人：TUROS EDWARD

  公开号：US20190133944A1

  公开（公告）日：2019-05-09

  The subject invention pertains to polyacrylate homopolymers produced from acrylolated drug monomers. The homopolymers can be produced in the form of nanoparticles. The nanoparticles comprising the homopolymers can be produced via a free radical-induced emulsion polymerization of the acrylolated drug monomers to produce an aqueous emulsion of uniformly sized nanoparticles. The homopolymers of the invention containing acrylolated antibiotic monomers can be active against Gram-positive and Gram-negative bacteria, such as Staphylococcus aureus and Escherichia coil. Accordingly, methods are provided of treating a disease, for example, an infection, by administering to a subject the homopolymers, homopolymeric nanoparticles, or emulsions containing homopolymeric nanoparticles of the invention.

  本发明涉及从丙烯酰基药物单体制备的聚丙烯酸酯均聚物。这些均聚物可以以纳米粒子的形式制备。通过自由基诱导的乳液聚合反应，可以将丙烯酰基药物单体聚合成均匀大小的纳米粒子的水性乳液。本发明中含有丙烯酰基抗生素单体的均聚物可以对革兰氏阳性和革兰氏阴性细菌具有活性，例如金黄色葡萄球菌和大肠杆菌。因此，本发明提供了通过向受体施用本发明中的均聚物、均聚纳米粒子或含有均聚纳米粒子的乳液来治疗疾病，例如感染的方法。