Paracetamol cysteine | 58109-87-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Paracetamol cysteine
• 英文别名: (4-acetamidophenyl) (2R)-2-amino-3-sulfanylpropanoate
• CAS: 58109-87-8
• 化学式: C₁₁H₁₄N₂O₃S
• 分子量: 254.31
• InChiKey: VKVHWTMZJQWYBR-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  82.4
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Glycosylated Acetaminophen Pro-Drug Analogs
  申请人：Shull Brian

  公开号：US20120022012A1

  公开（公告）日：2012-01-26

  The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs of the analgesic acetaminophen. This invention relates to a method for the production of a broad group of glycosides of acetaminophen derivatives.

  本发明涉及一种用于合成、生产和使用镇痛药扑热息痛的前药类似物的方法和组合物。本发明涉及一种用于生产扑热息痛衍生物的广泛群体的糖苷类物质的方法。
• HEPATOPROTECTANT ACETAMINOPHEN MUTUAL PRODRUGS
  申请人：Muhammad Naweed

  公开号：US20110263545A1

  公开（公告）日：2011-10-27

  The present invention provides hepatoprotectant acetaminophen mutual prodrugs, which have an acetaminophen moiety covalently linked to a second moiety that may act as a hepatoprotectant against acetaminophen hepatotoxicity. Additionally, acetaminophen mutual prodrugs may have improved water solubility which may provide better suitability for parenteral and other dosage forms relative to administration of acetaminophen. Also provided are methods of treating a disease or condition that is responsive to acetaminophen (such as fever, pain and ischemic injury) using hepatoprotectant acetaminophen mutual prodrugs, as well as kits and unit dosages.

  本发明提供了肝保护醋氨酚共价偶联物，其含有醋氨酚基团与第二基团共价结合，第二基团可能作为肝保护剂对抗醋氨酚肝毒性。此外，醋氨酚共价偶联物可能具有改善的水溶性，相对于醋氨酚的给药方式，更适合于静脉和其他剂型的使用。本发明还提供了使用肝保护醋氨酚共价偶联物治疗对醋氨酚具有反应的疾病或病况的方法（如发热、疼痛和缺血性损伤），以及套装和单元剂量。
• Acetaminophen adducts and methods of use thereof
  申请人：BioVentures, LLC

  公开号：US10351897B2

  公开（公告）日：2019-07-16

  The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts. The present disclosure provides acetaminophen (APAP)-protein adducts and methods of detecting acetaminophen-induced toxicity in a subject using APAP-protein adducts. One aspect of the present disclosure provides an APAP-protein adduct for diagnosing acetaminophen-induced toxicity. According to the present disclosure, the inventors have identified proteins that are modified by N-acetyl-pbenzoquinoneimine (NAPQI) in subjects with acetaminophen-induced toxicity. Non-limiting examples of proteins modified by NAPQI include betaine-homocysteine S-methyltransferase 1, cytoplasmic aspartate aminotransferase, 1,4-alpha-glucan branching enzyme, formimidoyltransferase-cyclodeaminase, and dystrophin.

  本公开涉及对乙酰氨基酚蛋白加合物和使用对乙酰氨基酚蛋白加合物诊断对乙酰氨基酚毒性的方法。本公开提供了对乙酰氨基酚（APAP）-蛋白加合物和使用对乙酰氨基酚-蛋白加合物检测对乙酰氨基酚诱导的受试者毒性的方法。本公开的一个方面提供了一种用于诊断对乙酰氨基酚诱导的毒性的 APAP 蛋白加合物。根据本公开内容，本发明人已经在对乙酰氨基酚诱发毒性的受试者中鉴定出了被 N-乙酰基苯醌亚胺（NAPQI）修饰的蛋白质。被 NAPQI 修饰的蛋白质的非限制性实例包括甜菜碱-高半胱氨酸 S-甲基转移酶 1、细胞质天门冬氨酸氨基转移酶、1,4-α-葡聚糖分支酶、甲酰亚胺基转移酶-环脱氨酶和肌营养蛋白。
• Anti-acetaminophen antibodies and acetaminophen protein adducts
  申请人：BioVentures, LLC

  公开号：US10570216B2

  公开（公告）日：2020-02-25

  The present disclosure provides isolated antibodies that bind to acetaminophen-protein adducts that are useful in the detection and diagnosis of acetaminophen-induced toxicity.

  本公开提供了与对乙酰氨基酚-蛋白质加合物结合的分离抗体，可用于检测和诊断对乙酰氨基酚引起的毒性。
• ACETAMINOPHEN-PROTEIN ADDUCT ASSAY DEVICE AND METHOD
  申请人：The Board of Trustees of The University of Arkansas

  公开号：EP2277040A1

  公开（公告）日：2011-01-26