五乙二醇单甲醚丙酸 | 1347750-72-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 五乙二醇单甲醚丙酸
• 中文别名: 甲基-PEG5-羧酸
• 英文名称: 2,5,8,11,14,17-hexaoxaicosan-20-oic acid
• 英文别名: m-PEG6-acid；3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid；m-PEG5-acid
• CAS: 1347750-72-4
• 化学式: C₁₄H₂₈O₈
• 分子量: 324.372
• InChiKey: YMWMTQPDLHRNCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  22
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  92.7
• 氢给体数：
  1
• 氢受体数：
  8

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  五乙二醇单甲醚丙酸 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 N,N-二异丙基乙胺 作用下， 以 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran 为溶剂， 反应 60.0h， 生成 (2,3,5,6-tetrafluorophenyl) (2S)-6-[3-[2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoate
  参考文献：
  名称：

  VHH ANTIBODY CONJUGATES WITH HETEROARYL CHELATORS

  摘要：

  Described herein are immunoconjugates comprising an: a) antigen binding region; b) an immunoglobulin heavy chain constant region; and c) a radioisotope chelating agent; wherein the molecular weight of said immunoconjugate is between 60 and 110 kDa. The immunoconjugates can be used to deliver alpha and beta emitters for the treatment of tumors or cancer.

  公开号：

  WO2024044554A1

文献信息

• [EN] COMPOUNDS FOR TREATING NEAR VISION DISORDERS<br/>[FR] COMPOSÉS POUR LE TRAITEMENT DE TROUBLES DE LA VISION DE PRÈS
  申请人：VIEWPOINT THERAPEUTICS INC

  公开号：WO2019108673A1

  公开（公告）日：2019-06-06

  Cataract and presbyopia affect billions of people worldwide. Described herein are new compounds and methods of treating and preventing these diseases.

  白内障和老视病影响全球数十亿人。本文描述了治疗和预防这些疾病的新化合物和方法。
• WO2019224790A5
  申请人：——

  公开号：WO2019224790A5

  公开（公告）日：2022-06-13
• Exploration of Alternative Scaffolds for P2Y₁₄ Receptor Antagonists Containing a Biaryl Core
  作者：Young-Hwan Jung、Jinha Yu、Zhiwei Wen、Veronica Salmaso、Tadeusz P. Karcz、Ngan B. Phung、Zhoumou Chen、Sierra Duca、John M. Bennett、Steven Dudas、Daniela Salvemini、Zhan-Guo Gao、Donald N. Cook、Kenneth A. Jacobson

  DOI：10.1021/acs.jmedchem.0c00745

  日期：2020.9.10

  Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y(14) receptor (P2Y(14)R) antagonists were synthesized, and affinity was measured in P2Y(14)R-expressing Chinese hamster ovary cells by flow cytometry. Given this series' low water solubility, various polyethylene glycol derivatives of the distally binding piperidin-4-yl moiety of moderate affinity were synthesized. Rotation of previously identified 1,2,3-triazole attached to the central m-benzoic acid core (25) provided moderate affinity but not indole and benzimidazole substitution of the aryl-triazole. The corresponding P2Y(14)R region is predicted by homology modeling as a deep, sterically limited hydrophobic pocket, with the outward pointing piperidine moiety being the most flexible. Bicyclic-substituted piperidine ring derivatives of naphthalene antagonist 1, e.g., quinuclidine 17 (MRS4608, IC50 approximate to 20 nM at hP2Y(14)R/mP2Y(14)R), or of triazole 2, preserved affinity. Potent antagonists 1, 7a, 17, and 23 (10 mg/kg) protected in an ovalbumin/Aspergillus mouse asthma model, and PEG conjugate 12 reduced chronic pain. Thus, we expanded P2Y(14)R antagonist structure-activity relationship, introducing diverse physical-chemical properties.
• PRODRUGS OF FULVESTRANT
  申请人：Kashiv Biosciences, LLC

  公开号：EP3801553A2

  公开（公告）日：2021-04-14
• US20140255306A1
  申请人：——

  公开号：US20140255306A1

  公开（公告）日：2014-09-11